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Weekly reads: heterochromatin, H3.3, Mesoblast bump – The Niche

My lab is focused in part on chromatin states in stem cells and cancer including heterochromatin. In fact, my lab’s website is chromatin.com. Heterochromatin is dense, often inactive chromatin. By H&E staining and electron microscopy, heterochromatin looks dark compared to the rest of the nucleus, largely composed of euchromatin.

Toward the end of my postdoc at The Hutch I found that loss of myc in neural stem cells leads to more heterochromatin. See the image below.

N-myc, heterochromatin
Loss of N-myc in neural stem cells leads to more heterochromatin. Embo J. 2006.

We also study the histone variant H3.3 so a new preprint on both H3.3 and chromatin is right up our alley. Let’s start with that.

Chromatin and heterochromatin

Other reads