“Several laboratories, including ours, about 20 years ago found at least 2 distinguishable HSC subsets in mice by transplantation assays: one subset, dominating in early life, made new T and B lymphocytes more than innate immunity cells such as granulocytes and macrophages. But in aging mice, these were largely displaced by myeloid-biased HSCs that produce few new lymphocytes, but many more innate immunity cells”, explains Irving Weissman, one of the corresponding authors of the study.
Although many factors, including age-related changes in the local microenvironment, are known to contribute to immunosenescence, the team hypothesized that depleting these myeloid-biased HSCs could rebalance the aged immune system.
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- Source: https://www.nature.com/articles/s43587-024-00637-9