{"id":621760,"date":"2024-06-24T20:00:00","date_gmt":"2024-06-25T00:00:00","guid":{"rendered":"https:\/\/platohealth.ai\/genomic-barcoding-for-clonal-diversity-monitoring-and-control-in-cell-based-complex-antibody-production-scientific-reports\/"},"modified":"2024-06-25T09:00:31","modified_gmt":"2024-06-25T13:00:31","slug":"genomic-barcoding-for-clonal-diversity-monitoring-and-control-in-cell-based-complex-antibody-production-scientific-reports","status":"publish","type":"post","link":"https:\/\/platohealth.ai\/genomic-barcoding-for-clonal-diversity-monitoring-and-control-in-cell-based-complex-antibody-production-scientific-reports\/","title":{"rendered":"Genomic barcoding for clonal diversity monitoring and control in cell-based complex antibody production – Scientific Reports","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"
We were interested in the cellular population diversity at different stages of an isogenic TI CLD platform22<\/a><\/sup>. This platform is based on simultaneous dual-plasmid RMCE-mediated targeted integration into a single genomic locus thus generating isogenic cells, which theoretically excludes variability derived from position effects, copy number and epigenetic silencing (Fig. 1<\/a>a).<\/p>\n