{"id":605672,"date":"2024-06-04T12:55:00","date_gmt":"2024-06-04T16:55:00","guid":{"rendered":"https:\/\/platohealth.ai\/asco-2024-merus-charges-ahead-with-positive-hnscc-results\/"},"modified":"2024-06-04T16:49:35","modified_gmt":"2024-06-04T20:49:35","slug":"asco-2024-merus-charges-ahead-with-positive-hnscc-results","status":"publish","type":"post","link":"https:\/\/platohealth.ai\/asco-2024-merus-charges-ahead-with-positive-hnscc-results\/","title":{"rendered":"ASCO 2024: Merus charges ahead with positive HNSCC results","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"

On Monday, 3 June at the American Society of Clinical Oncology (ASCO)<\/a> annual meeting, Merus<\/a> shared interim results from the Phase I\/II trial (NCT03526835) comparing its \u201cfirst-in-class\u201d petosemtamab<\/a>, a bispecific monoclonal antibody targeting EGFR and LGR5, in combination with MSD\u2019s Keytruda (pembrolizumab), against Keytruda alone in first-line recurrent\/metastatic (r\/m) head and neck squamous cell carcinoma (HNSCC).<\/p>\n

Up to 80-90% of HNSCC tumours overexpress EGFR or harbour EGFR mutations. In March 2024, the US Food and Drug Administration (FDA) granted petosemtamab a breakthrough therapy designation. The combination therapy is also currently in Phase I\/II trials as a second-line treatment amongst other uses in multiple solid tumours including HNSCC and non-small cell lung cancer. The standard of care first-line treatment for HNSCC is treatment with Keytruda with or without chemotherapy, while in the second-line it is chemotherapy with or without Eli Lilly\u2019s Erbitux (cetuximab), an EGFR-directed antibody.<\/p>\n

The Phase I\/II trial enrolled 45 patients, of which 24 were analysed before the data cutoff date. Of the 24 patients analysed, 16 patients responded to the treatment, demonstrating a 67% objective response rate (ORR) and of the 16 responders, 14 people continued with the therapy after the cutoff date. Responses were consistent across cancers related to HPV and unrelated to HPV as well as consistent regardless of PD-L1 composite score. This compared favourably to the Phase III KEYNOTE-048 study (NCT02358031), which tested Keytruda alone or Keytruda with chemotherapy in a similar patient population, in which the ORR was 23.3% and 43.7%, respectively. Furthermore, in Merus\u2019 trial, 40% of patients experienced grade 3 or higher adverse events (AEs), but only two patients (4%) discontinued treatment due to treatment-related AEs. In KEYNOTE-048, grade 3 and above AEs were reported in 17.0% of the Keytuda alone arm and in 71.7% of the Keytuda and chemotherapy arm. Merus plans to commence a Phase III registrational trial in mid-2024 for the second-line treatment of HNSCC and beyond, with a Phase III registrational trial in first-line HNSCC planned to start by the end of the year.<\/p>\n

Petosemtamab\u2019s novel therapeutic mechanism, using dual targeting of the EGFR pathway, has a chance to shake up the treatment of EGFR-mutated cancer. Erbitux currently dominates second-line HNSCC<\/a>, which has a high rate of EGFR mutation but will likely lose a share of the market to petosemtamab if approved in second-line and beyond. However, there are much greater gains to be made in the first line, and Merus\u2019 combination with Keytruda could provide much better clinical efficacy and safety outcomes compared to Erbitux. HNSCC is not the only indication petosemtamab can make waves in, as EGFR mutated NSCLC is a significant market currently dominated by AstraZeneca<\/a>\u2019s Tagrisso (osimertinib), an EGFR targeting tyrosine kinase inhibitor (TKI). It is possible that petosemtamab could move into the same line of therapy and compete with Tagrisso or provide a potential partner in a strong anti-EGFR mutant combination.<\/p>\n

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