{"id":605416,"date":"2024-06-04T04:20:43","date_gmt":"2024-06-04T08:20:43","guid":{"rendered":"https:\/\/platohealth.ai\/moderna-and-msd-share-encouraging-three-year-data-from-trial-of-melanoma-therapy\/"},"modified":"2024-06-04T07:50:07","modified_gmt":"2024-06-04T11:50:07","slug":"moderna-and-msd-share-encouraging-three-year-data-from-trial-of-melanoma-therapy","status":"publish","type":"post","link":"https:\/\/platohealth.ai\/moderna-and-msd-share-encouraging-three-year-data-from-trial-of-melanoma-therapy\/","title":{"rendered":"Moderna and MSD share encouraging three-year data from trial of melanoma therapy","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<div class=\"article-image\">\n<figure class=\"article-image__container\">\n<p>                                    <img decoding=\"async\" src=\"https:\/\/platohealth.ai\/wp-content\/uploads\/2024\/06\/moderna-and-msd-share-encouraging-three-year-data-from-trial-of-melanoma-therapy.jpg\" alt><figcaption class=\"c-featured-image__description\">The trial enrolled 157 patients, who were givne the combination therapy or KEYTRUDA alone following surgery. Credit: Gorodenkoff \/ Shutterstock.<\/figcaption><\/figure>\n<\/p><\/div>\n<figure class=\"wp-block-image size-large is-resized\" id=\"https:\/\/www.trilinkbiotech.com\/\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"101\" src=\"https:\/\/platohealth.ai\/wp-content\/uploads\/2024\/06\/moderna-and-msd-share-encouraging-three-year-data-from-trial-of-melanoma-therapy-1.jpg\" alt class=\"wp-image-205171\"><\/figure>\n<p class=\"drop-cap\">Pharmaceutical companies <a rel=\"noopener\" target=\"_blank\" href=\"https:\/\/www.globaldata.com\/store\/report\/?cdmsid=1601879&amp;scalar=true&amp;utm_source=Company News&amp;utm_medium=22-206957&amp;utm_campaign=company-profile-hyperlink-nonlgp\">Moderna<\/a> and Merck &amp; Co (MSD) have <a rel=\"noopener\" target=\"_blank\" href=\"https:\/\/news.modernatx.com\/news\/news-details\/2024\/Moderna--Merck-Announce-3-Year-Data-For-mRNA-4157-V940-in-Combination-With-KEYTRUDAR-pembrolizumab-Demonstrated-Sustained-Improvement-in-Recurrence-Free-Survival--Distant-Metastasis-Free-Survival-Versus-KEYTRUDA-in-Patients-With-High-Risk-Stage-IIIIV\/default.aspx\">announced positive results<\/a> from the Phase IIb KEYNOTE-942\/mRNA-4157-P201 study of mRNA-4157 (V940) plus Keytruda to treat high-risk melanoma (stage III\/IV) following complete resection.<\/p>\n<p>            <!-- sponsored-whitepaper sponsored hidden sponsored-with-form --><\/p>\n<p>mRNA-4157 is an investigational messenger ribonucleic acid (mRNA) individualised neoantigen therapy (INT).<\/p>\n<div class=\"gdm-company-profile-unit__container\" id=\"company_profile_form\">\n<p class=\"gdm-company-profile-unit__sub-heading\">Access the most comprehensive Company Profiles<br \/>\n            on the market, powered by GlobalData. 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Gain competitive edge.<\/p>\n<p>        <button class=\"gdm-company-profile-unit__button\"><a rel=\"noopener\" target=\"_blank\" href=\"https:\/\/www.globaldata.com\/companies\/?utm_source=News&amp;utm_term=visit_company_profile&amp;utm_content=Moderna and MSD share encouraging three-year data from trial of melanoma therapy\">View profiles in store<\/a><\/button><\/p>\n<div class=\"gdm-company-profile-unit__profile-container\">\n<div class=\"gdm-company-profile-unit__image-container\">\n<p>                <img decoding=\"async\" src=\"https:\/\/platohealth.ai\/wp-content\/uploads\/2024\/06\/moderna-and-msd-share-encouraging-three-year-data-from-trial-of-melanoma-therapy.png\" alt>\n            <\/div>\n<div class=\"gdm-company-profile-unit__form-container\">\n<p>                <span class=\"gdm-company-profile-unit__form-excerpt\">Company Profile \u2013 free<br \/>\n                    sample<\/span><\/p>\n<div id=\"form-thank-you-container\" class=\"gdm-company-profile-unit__thank-you-container\">\n<p>Your download email will arrive shortly<\/p>\n<\/p><\/div>\n<div id=\"gdm-form-wrapper\" class=\"gdm-company-profile-unit__form-wrapper\">\n<p class=\"gdm-company-profile-unit__form-sub-heading\">We are confident about the<br \/>\n                        unique<br \/>\n                        quality of our Company Profiles. However, we want you to make the most<br \/>\n                        beneficial<br \/>\n                        decision for your business, so we offer a free sample that you can download by<br \/>\n                        submitting the below form\n                    <\/p>\n<p>                    <span class=\"gdm-company-profile-unit__text\">By GlobalData<\/span><\/p>\n<div class=\"reveal-form__wrapper\">\n<p>                                <small><\/small><\/p>\n<p>                            <small><\/small>\n                        <\/p>\n<p>                        <label for=\"consent-box\">Tick here to opt out of curated industry news, reports, and event updates from Clinical Trials Arena.<\/label>\n                        <\/p>\n<p>                            &lt;!&#8211;<\/p>\n<div class=\"form-consent__container\">\n<p>                                <label for=\"consent-box\">I consent to GlobalData UK Limited collecting<br \/>\n                                    my<br \/>\n                                    details provided via this form in accordance with the privacy<br \/>\n                                    policy<\/label>\n                            <\/div>\n<p>&#8211;&gt;<\/p>\n<p>\n                                <button id=\"form-submit-btn\" class=\"form-submit__button button primary solid\"><br \/>\n                                    Submit and<br \/>\n                                    download<\/button>\n                            <\/p>\n<p>                                    <span class=\"inline\">Visit our <a rel=\"noopener\" target=\"_blank\" href=\"https:\/\/www.verdict.co.uk\/privacy-policy\/\">Privacy Policy<\/a> for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.<\/span><\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<p>The data showed a sustained improvement in recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) following treatment with mRNA-4157 plus KEYTRUDA regimen compared with Keytruda alone.<\/p>\n<p>The open-label, randomised trial enrolled 157 patients who received the combination therapy or Keytruda alone post-surgery.<\/p>\n<p>RFS was the trial\u2019s primary endpoint while secondary endpoints included DMFS and safety.<\/p>\n<p>According to the latest data with a median follow-up of nearly three years, the combination regimen reduced the recurrence or mortality risk by 49% and the risk of developing distant metastasis or death by 62%.<\/p>\n<p>These findings build on earlier analyses and demonstrate a significant benefit across various subgroups, regardless of tumour mutational burden or PD-L1 status.<\/p>\n<p>The exploratory analysis also indicated an overall survival benefit, with a 2.5-year OS rate of 96.0% for the combination therapy versus 90.2% for Keytruda alone.<\/p>\n<p>mRNA-4157 (V940) regimen\u2019s safety profile was in line with initial assessment data, with most adverse events observed to be mild to moderate in severity.<\/p>\n<p>MSD and Moderna continue to collect additional translational findings, with a further 100 subjects being enrolled in the ongoing trial.<\/p>\n<p>Moderna development, therapeutics and oncology head Kyle Holen said: \u201cWe are encouraged by the latest results from the KEYNOTE-942\/mRNA-4157-P201 study.<\/p>\n<p>\u201cThese findings reinforce our commitment to advancing this innovative treatment in collaboration with Merck, and we are dedicated to harnessing mRNA technology to potentially transform cancer therapy and improve patient outcomes.\u201d<\/p>\n<p>In December 2023, the two companies <a rel=\"noopener\" target=\"_blank\" href=\"https:\/\/www.clinicaltrialsarena.com\/news\/merck-moderna-cancer-vaccine-keytruda-trial-nsclc\/\">enrolled the first subjects in the Phase III INTerpath-002 study<\/a> of mRNA-4157 plus Keytruda for non-small cell lung cancer (NSCLC).<\/p>\n<p><em>mRNA vaccine coverage on Pharmaceutical Technology (Or Clinical Trials Arena) &nbsp;is supported by Trilink<\/em>. <em>Editorial content is independently produced and follows the <\/em><a rel=\"noopener\" target=\"_blank\" href=\"https:\/\/www.clinicaltrialsarena.com\/editorial-standards\/\">highest standards<\/a> <em>of journalistic integrity. 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Pharmaceutical companies Moderna and Merck &amp; Co (MSD) have announced positive results from the Phase IIb KEYNOTE-942\/mRNA-4157-P201 study of mRNA-4157 (V940) plus Keytruda to treat high-risk melanoma (stage III\/IV) following complete resection. mRNA-4157 is an [&hellip;]<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":2,"featured_media":605423,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[49],"tags":[],"acf":[],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts\/605416"}],"collection":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/comments?post=605416"}],"version-history":[{"count":1,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts\/605416\/revisions"}],"predecessor-version":[{"id":605422,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts\/605416\/revisions\/605422"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/media\/605423"}],"wp:attachment":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/media?parent=605416"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/categories?post=605416"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/tags?post=605416"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}