{"id":603179,"date":"2024-05-31T20:00:00","date_gmt":"2024-06-01T00:00:00","guid":{"rendered":"https:\/\/platohealth.ai\/i%ce%bab%ce%b1-controls-dormancy-in-hematopoietic-stem-cells-via-retinoic-acid-during-embryonic-development-nature-communications\/"},"modified":"2024-06-01T11:18:43","modified_gmt":"2024-06-01T15:18:43","slug":"i%ce%bab%ce%b1-controls-dormancy-in-hematopoietic-stem-cells-via-retinoic-acid-during-embryonic-development-nature-communications","status":"publish","type":"post","link":"https:\/\/platohealth.ai\/i%ce%bab%ce%b1-controls-dormancy-in-hematopoietic-stem-cells-via-retinoic-acid-during-embryonic-development-nature-communications\/","title":{"rendered":"I\u03baB\u03b1 controls dormancy in hematopoietic stem cells via retinoic acid during embryonic development – Nature Communications","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"
To understand the precise involvement of the inflammatory signaling pathways throughout HSC ontogeny, we scrutinized a publicly available dataset of single-cell sequencing of HSCs at various stages of development, i.e., AGM, FL, and bone marrow13<\/a><\/sup>. Cells clustered according to their cell fate, with AGM endothelial cells (EC) situated at the opposing end to the bone marrow HSCs (Fig. 1A<\/a>). In between these two fates, the T1\/T2 HSC of the AGM, and the FL HSCs (E12.5 and E14.5) formed a continuum towards the bone marrow HSCs (Fig. 1A<\/a>).<\/p>\n