{"id":497546,"date":"2024-01-26T19:30:51","date_gmt":"2024-01-27T00:30:51","guid":{"rendered":"https:\/\/platohealth.ai\/genentechs-i-shaped-abs-a-bispecific-dendritic-t-cell-engager-and-more\/"},"modified":"2024-01-27T07:15:44","modified_gmt":"2024-01-27T12:15:44","slug":"genentechs-i-shaped-abs-a-bispecific-dendritic-t-cell-engager-and-more","status":"publish","type":"post","link":"https:\/\/platohealth.ai\/genentechs-i-shaped-abs-a-bispecific-dendritic-t-cell-engager-and-more\/","title":{"rendered":"Genentech\u2019s i-shaped Abs; a bispecific dendritic-T cell engager and more","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"
ARTICLE | Discovery & Translation<\/p>\n
\n By Danielle Golovin, Senior Biopharma Analyst<\/span>\n<\/p>\n January 27, 2024 12:30 AM UTC<\/p>\n<\/div>\n<\/div>\n<\/div>\n The Genentech Inc. unit of Roche<\/a> (SIX:ROG; OTCQX:RHHBY) reported<\/a> in Nature Communications<\/i> i-shaped antibody agonists that more closely recapitulate the biology of natural ligands than traditional Y-shaped antibodies. By adjusting the geometry by which the IgG Fab arms engage target receptors, the scientists were able to create monospecific i-shaped antibody agonists of several tumor necrosis factor receptor superfamily members and bispecific agonists of IL-2RB and IL-2RG.<\/p>\n Researchers from Weizmann Institute of Science<\/a> and Tel Aviv University<\/a> published<\/a> in Cell<\/i> a bispecific DC-T cell engager (BiCE) that facilitates interaction between PD-1+<\/sup> T cells and CLEC9A+<\/sup> conventional type I dendritic cells. The BiCE enhanced tumor-specific T cell proliferation and remodeled tumor-infiltrating lymphocyte states and frequencies to favor tumor elimination in mouse models of cancer, including ones resistant to traditional anti-PD-1 therapy…<\/p>\n ARTICLE | Discovery & Translation BioCentury\u2019s roundup of translational innovations By Danielle Golovin, Senior Biopharma Analyst January 27, 2024 12:30 AM UTC The Genentech Inc. unit of Roche (SIX:ROG; OTCQX:RHHBY) reported in Nature Communications i-shaped antibody agonists that more closely recapitulate the biology of natural ligands than traditional Y-shaped antibodies. By adjusting the geometry by which the IgG […]<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":2,"featured_media":497550,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[50],"tags":[],"acf":[],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts\/497546"}],"collection":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/comments?post=497546"}],"version-history":[{"count":1,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts\/497546\/revisions"}],"predecessor-version":[{"id":497549,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts\/497546\/revisions\/497549"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/media\/497550"}],"wp:attachment":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/media?parent=497546"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/categories?post=497546"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/tags?post=497546"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}<\/span><\/div>\n
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