{"id":482475,"date":"2024-01-11T12:24:25","date_gmt":"2024-01-11T17:24:25","guid":{"rendered":"https:\/\/platohealth.ai\/put-on-a-happy-face-perspectives-on-mayo-clinic-stem-cells-for-heart-disease-ph3-pub-the-niche\/"},"modified":"2024-01-11T17:09:21","modified_gmt":"2024-01-11T22:09:21","slug":"put-on-a-happy-face-perspectives-on-mayo-clinic-stem-cells-for-heart-disease-ph3-pub-the-niche","status":"publish","type":"post","link":"https:\/\/platohealth.ai\/put-on-a-happy-face-perspectives-on-mayo-clinic-stem-cells-for-heart-disease-ph3-pub-the-niche\/","title":{"rendered":"Put on a happy face? Perspectives on Mayo Clinic stem cells for heart disease Ph3 pub – The Niche","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"
One of the first regenerative medicine talks I ever saw was on stem cells for heart disease. I was still a trainee at the time. The professor, whom I won\u2019t name, presented data from an early phase trial reporting that direct injections of some kind of cells right into the heart improved outcomes.<\/p>\n
It sounded exciting but maybe too good to be true, and, in the end, it wasn\u2019t replicated in the years that followed.<\/p>\n Since then, there have been dozens of different cell therapy clinical studies in this cardiovascular area. Mostly these studies report small possible benefits just from post-hoc analysis. However, often the studies are initially hyped in the media anyway.<\/p>\n For broader background on stem cells for heart disease, see this post I did last year: stem cell therapy for heart disease.<\/strong><\/a><\/p>\n There is such a need for novel approaches to various forms of cardiovascular disease. I keep hoping a cellular approach might be rigorously proven to work and be safe. I also keep an eye open for new trials and papers.<\/p>\n A new trial paper from The Mayo Clinic caught my eye in this space. The new paper reports on a Phase III trial with a heavy emphasis on patient perceptions of quality of life. There are some unusual things about this publication. Graphical abstract from Yamada et al. SCTM paper on stem cells for heart disease. <\/strong><\/em>What do you think of using smiley and sad faces in an academic publication?<\/p>\n<\/p>\n
Phase 3 trial<\/h2>\n