{"id":481437,"date":"2024-01-09T19:00:00","date_gmt":"2024-01-10T00:00:00","guid":{"rendered":"https:\/\/platohealth.ai\/effects-of-fine-particulate-matter-on-bone-marrow-conserved-hematopoietic-and-mesenchymal-stem-cells-a-systematic-review-experimental-molecular-medicine\/"},"modified":"2024-01-10T06:13:10","modified_gmt":"2024-01-10T11:13:10","slug":"effects-of-fine-particulate-matter-on-bone-marrow-conserved-hematopoietic-and-mesenchymal-stem-cells-a-systematic-review-experimental-molecular-medicine","status":"publish","type":"post","link":"https:\/\/platohealth.ai\/effects-of-fine-particulate-matter-on-bone-marrow-conserved-hematopoietic-and-mesenchymal-stem-cells-a-systematic-review-experimental-molecular-medicine\/","title":{"rendered":"Effects of fine particulate matter on bone marrow-conserved hematopoietic and mesenchymal stem cells: a systematic review – Experimental & Molecular Medicine","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"
<\/div>\n
  • \n

    Dockery, D. W. et al. An association between air pollution and mortality in six US cities. N. Engl. J. Med.<\/i> 329<\/b>, 1753\u20131759 (1993).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Lippmann, M., Yeates, D., Albert, R. J. O. & Medicine, E. Deposition, retention, and clearance of inhaled particles. Br. J. Ind. Med.<\/i> 37<\/b>, 337\u2013362 (1980).<\/p>\n

    CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Kappos, A. D. et al. Health effects of particles in ambient air. Int. J. Hyg. Environ. Health<\/i> 207<\/b>, 399\u2013407 (2004).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Kelly, F. J. & Fussell, J. C. Air pollution and public health: emerging hazards and improved understanding of risk. Environ. Geochem. Health<\/i> 37<\/b>, 631\u2013649 (2015).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Lee, M. An analysis on the concentration characteristics of PM2.5 in Seoul, Korea from 2005 to 2012. Asia Pac. J. Atmos. Sci.<\/i> 50<\/b>, 585\u2013594 (2014).<\/p>\n

    Article<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Research, N.I.o.E. (National Institute of Environmental Research Incheon, Korea, (2017).<\/p>\n<\/li>\n

  • \n

    Jia, H. et al. PM2.5\u2010induced pulmonary inflammation via activating of the NLRP3\/caspase\u20101 signaling pathway. Environ. Toxicol.<\/i> 36<\/b>, 298\u2013307 (2021).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Duan, Z. et al. Effects of PM2. 5 exposure on Klebsiella pneumoniae clearance in the lungs of rats. Zhonghua jie he he hu xi za zhi= Zhonghua jiehe he huxi zazhi= Chin. J. tuberculosis respiratory Dis.<\/i> 36<\/b>, 836\u2013840 (2013).<\/p>\n


    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Longhin, E. et al. Cell cycle alterations induced by urban PM2. 5 in bronchial epithelial cells: characterization of the process and possible mechanisms involved. Part. Fibre Toxicol.<\/i> 10<\/b>, 1\u201319 (2013).<\/p>\n

    Article<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Jin, X.-T. et al. Progression and inflammation of human myeloid leukemia induced by ambient PM 2.5 exposure. Arch. Toxicol.<\/i> 90<\/b>, 1929\u20131938 (2016).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Blank, F., von Garnier, C., Gehr, P. & Rothen-Rutishauser, B. Translocation across the air-blood tissue barrier. (CRC Press, 2014).<\/p>\n<\/li>\n

  • \n

    Reed, J. R., dela Cruz, A. L. N., Lomnicki, S. M. & Backes, W. L. Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2. Toxicol. Appl. Pharmacol.<\/i> 289<\/b>, 223\u2013230 (2015).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Oberd\u00f6rster, G., Oberd\u00f6rster, E. & Oberd\u00f6rster, J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect.<\/i> 113<\/b>, 823\u2013839 (2005).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Casals, E., V\u00e1zquez-Campos, S., Bast\u00fas, N. G. & Puntes, V. Distribution and potential toxicity of engineered inorganic nanoparticles and carbon nanostructures in biological systems. TrAC Trends Anal. Chem.<\/i> 27<\/b>, 672\u2013683 (2008).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Xu, J.-J. et al. Relationship between PM 2. 5 exposure and pulmonary function in different working environments. J. Environ. Health<\/i> 30<\/b>, 1\u20134 (2013).<\/p>\n


    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Xing, Y.-F., Xu, Y.-H., Shi, M.-H. & Lian, Y.-X. The impact of PM2. 5 on the human respiratory system. J. Thorac. Dis.<\/i> 8<\/b>, E69 (2016).<\/p>\n

    PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Cheng, Y. et al. Ambient PM2. 5 during pregnancy and risk on preterm birth. Zhonghua liu xing bing. xue za zhi= Zhonghua liuxingbingxue zazhi<\/i> 37<\/b>, 572\u2013577 (2016).<\/p>\n

    CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Shu, Y. et al. Analysis of the relationship between PM2. 5 and lung cancer based on protein-protein interactions. Combinatorial Chem. high. throughput Screen.<\/i> 19<\/b>, 100\u2013108 (2016).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Wu, J., Zhu, J., Li, W., Xu, D. & Liu, J. Estimation of the PM 2.5 health effects in China during 2000\u20132011. Environ. Sci. Pollut. Res.<\/i> 24<\/b>, 10695\u201310707 (2017).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Shi, T. et al. Association between PM2. 5 air pollution and daily resident mortality in Guangzhou urban area in winter. J. Environ. Health<\/i> 32<\/b>, 477\u2013481 (2015).<\/p>\n


    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Chen, Y., Wong, G. W. & Li, J. Environmental exposure and genetic predisposition as risk factors for asthma in China. Allergy, Asthma Immunol. Res.<\/i> 8<\/b>, 92\u2013100 (2016).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Zhang, Y. et al. Correlational study on atmospheric concentrations of fine particulate matter and children cough variant asthma. Eur. Rev. Med. Pharm. Sci.<\/i> 20<\/b>, 2650\u20132654 (2016).<\/p>\n


    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Xie, G. et al. Effects of PM2. 5 and its constituents on hemoglobin during the third trimester in pregnant women. Environ. Sci. Pollut. Res.<\/i> 29<\/b>, 35193\u201335203 (2022).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Seita, J. & Weissman, I. L. Hematopoietic stem cell: self\u2010renewal versus differentiation. Wiley Interdiscip. Rev.: Syst. Biol. Med.<\/i> 2<\/b>, 640\u2013653 (2010).<\/p>\n

    CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Verovskaya, E. V., Dellorusso, P. V. & Passegu\u00e9, E. Losing sense of self and surroundings: hematopoietic stem cell aging and leukemic transformation. Trends Mol. Med.<\/i> 25<\/b>, 494\u2013515 (2019).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Till, J. E. & McCulloch, E. A. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat. Res.<\/i> 178<\/b>, AV3\u2013AV7 (2012).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Wei, Q. & Frenette, P. S. Niches for hematopoietic stem cells and their progeny. Immunity<\/i> 48<\/b>, 632\u2013648 (2018).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Yamada, T., Park, C. S. & Lacorazza, H. D. Genetic control of quiescence in hematopoietic stem cells. Cell Cycle<\/i> 12<\/b>, 2376\u20132383 (2013).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Cabezas-Wallscheid, N. et al. Vitamin A-retinoic acid signaling regulates hematopoietic stem cell dormancy. Cell<\/i> 169<\/b>, 807\u2013823. (2017).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Shenghui, H., Nakada, D. & Morrison, S. J. Mechanisms of stem cell self-renewal. Annu. Rev. Cell Developmental<\/i> 25<\/b>, 377\u2013406 (2009).<\/p>\n

    Article<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Hinge, A. et al. Asymmetrically segregated mitochondria provide cellular memory of hematopoietic stem cell replicative history and drive HSC attrition. Cell Stem Cell<\/i> 26<\/b>, 420\u2013430. (2020).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Inaba, M. & Yamashita, Y. M. Asymmetric stem cell division: precision for robustness. Cell Stem Cell<\/i> 11<\/b>, 461\u2013469 (2012).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Suda, T., Arai, F. & Hirao, A. Hematopoietic stem cells and their niche. Trends Immunol.<\/i> 26<\/b>, 426\u2013433 (2005).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Majeti, R., Park, C. Y. & Weissman, I. L. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell<\/i> 1<\/b>, 635\u2013645 (2007).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Dominici, M. et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy<\/i> 8<\/b>, 315\u2013317 (2006).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Pittenger, M. F. et al. Multilineage potential of adult human mesenchymal stem cells. Science<\/i> 284<\/b>, 143\u2013147 (1999).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Wagner, W. et al. Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp. Hematol.<\/i> 33<\/b>, 1402\u20131416 (2005).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Zhang, X. et al. Runx2 overexpression enhances osteoblastic differentiation and mineralization in adipose-derived stem cells in vitro and in vivo. Calcif. tissue Int.<\/i> 79<\/b>, 169\u2013178 (2006).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Kita, K., Gauglitz, G. G., Phan, T. T., Herndon, D. N. & Jeschke, M. G. Isolation and characterization of mesenchymal stem cells from the sub-amniotic human umbilical cord lining membrane. Stem Cells Dev.<\/i> 19<\/b>, 491\u2013502 (2010).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Ullah, I., Subbarao, R. B. & Rho, G. J. Human mesenchymal stem cells-current trends and future prospective. Biosci. Rep.<\/i> 35<\/b>, 1\u201318 (2015).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Ranera, B. et al. Expansion under hypoxic conditions enhances the chondrogenic potential of equine bone marrow-derived mesenchymal stem cells. Vet. J.<\/i> 195<\/b>, 248\u2013251 (2013).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Zhang, X. et al. Isolation and characterization of mesenchymal stem cells from human umbilical cord blood: reevaluation of critical factors for successful isolation and high ability to proliferate and differentiate to chondrocytes as compared to mesenchymal stem cells from bone marrow and adipose tissue. J. Cell. Biochem.<\/i> 112<\/b>, 1206\u20131218 (2011).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Gronthos, S., Graves, S., Ohta, S. & Simmons, P. The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors. Blood<\/i> 84<\/b>, 4164\u20134173 (1994).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Muruganandan, S., Roman, A. & Sinal, C. Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program. Cell. Mol. life Sci.<\/i> 66<\/b>, 236\u2013253 (2009).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Stock, P., Br\u00fcckner, S., Winkler, S., Dollinger, M. M. & Christ, B. Human bone marrow mesenchymal stem cell-derived hepatocytes improve the mouse liver after acute acetaminophen intoxication by preventing progress of injury. Int. J. Mol. Sci.<\/i> 15<\/b>, 7004\u20137028 (2014).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Xu, W. et al. Mesenchymal stern cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro. Exp. Biol. Med.<\/i> 229<\/b>, 623\u2013631 (2004).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Tang, D.-Q. et al. In vitro generation of functional insulin-producing cells from human bone marrow-derived stem cells, but long-term culture running risk of malignant transformation. Am. J. Stem Cells<\/i> 1<\/b>, 114 (2012).<\/p>\n

    CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Phadnis, S. M. et al. Human bone marrow-derived mesenchymal cells differentiate and mature into endocrine pancreatic lineage in vivo. Cytotherapy<\/i> 13<\/b>, 279\u2013293 (2011).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Gabr, M. M. et al. Insulin-producing cells from adult human bone marrow mesenchymal stem cells control streptozotocin-induced diabetes in nude mice. Cell Transplant.<\/i> 22<\/b>, 133\u2013145 (2013).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Barzilay, R., Ben-Zur, T., Bulvik, S., Melamed, E. & Offen, D. Lentiviral delivery of LMX1a enhances dopaminergic phenotype in differentiated human bone marrow mesenchymal stem cells. Stem Cells Dev.<\/i> 18<\/b>, 591\u2013602 (2009).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Wilkins, A. et al. Human bone marrow-derived mesenchymal stem cells secrete brain-derived neurotrophic factor which promotes neuronal survival in vitro. Stem Cell Res.<\/i> 3<\/b>, 63\u201370 (2009).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Bhattarai, G. et al. Maternal exposure to fine particulate matter during pregnancy induces progressive senescence of hematopoietic stem cells under preferential impairment of the bone marrow microenvironment and aids development of myeloproliferative disease. Leukemia<\/i> 34<\/b>, 1481\u20131484 (2020).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Bov\u00e9, H. et al. Ambient black carbon particles reach the fetal side of human placenta. Nat. Commun.<\/i> 10<\/b>, 3866 (2019).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Leachi, H. F. L. et al. Polycyclic aromatic hydrocarbons and development of respiratory and cardiovascular diseases in workers. Rev. Bras. Enferm.<\/i> 73<\/b>, e20180965 (2020).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Alegbeleye, O. O., Opeolu, B. O. & Jackson, V. A. Polycyclic aromatic hydrocarbons: a critical review of environmental occurrence and bioremediation. Environ. Manag.<\/i> 60<\/b>, 758\u2013783 (2017).<\/p>\n

    Article<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Zhao, C.-N. et al. Emerging role of air pollution in autoimmune diseases. Autoimmun. Rev.<\/i> 18<\/b>, 607\u2013614 (2019).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Puri, P., Nandar, S. K., Kathuria, S. & Ramesh, V. Effects of air pollution on the skin: A review. Indian J. Dermatol. Venereol. Leprol.<\/i> 83<\/b>, 415 (2017).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Ashmore, M.R. et al. World Atlas of Atmospheric Pollution, 77\u201394 (2008).<\/p>\n<\/li>\n

  • \n

    Grzywa-Celi\u0144ska, A., Krusi\u0144ski, A. & Milanowski, J. \u2018Smoging kills\u2019-effects of air pollution on human respiratory system. Ann. Agric. Environ. Med.<\/i> 27<\/b>, 1\u20135 (2020).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Kitamura, H. et al. Impact of secondary generated minerals on toxic element immobilization for air pollution control fly ash of a municipal solid waste incinerator. Environ. Sci. Pollut. Res.<\/i> 25<\/b>, 20700\u201320712 (2018).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    \u0160v\u00e9dov\u00e1, B. et al. Concentration variability of water-soluble ions during the acceptable and exceeded pollution in an industrial region. Int. J. Environ. Res. Public Health<\/i> 17<\/b>, 3447 (2020).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Shahrbaf, M. A., Akbarzadeh, M. A., Tabary, M. & Khaheshi, I. Air pollution and cardiac arrhythmias: A comprehensive review. Curr. Probl. Cardiol.<\/i> 46<\/b>, 100649 (2021).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Bangar, V., Mishra, A. K., Jangid, M. & Rajput, P. Elemental characteristics and source-apportionment of PM2. 5 during the post-monsoon season in Delhi, India. Front. Sustain. Cities<\/i> 3<\/b>, 648551 (2021).<\/p>\n

    Article<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Luckett, W. P. Origin and differentiation of the yolk sac and extraembryonic mesoderm in presomite human and rhesus monkey embryos. Am. J. Anat.<\/i> 152<\/b>, 59\u201397 (1978).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Onoda, A., Takeda, K. & Umezawa, M. Dose-dependent induction of astrocyte activation and reactive astrogliosis in mouse brain following maternal exposure to carbon black nanoparticle. Part. Fibre Toxicol.<\/i> 14<\/b>, 1\u201316 (2017).<\/p>\n

    Article<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Lelieveld, J., Evans, J. S., Fnais, M., Giannadaki, D. & Pozzer, A. The contribution of outdoor air pollution sources to premature mortality on a global scale. Nature<\/i> 525<\/b>, 367\u2013371 (2015).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Puett, R. C. et al. Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population. Br. J. Cancer<\/i> 123<\/b>, 1818\u20131824 (2020).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Cui, Y. et al. Ambient fine particulate matter induces apoptosis of endothelial progenitor cells through reactive oxygen species formation. Cell. Physiol. Biochem.<\/i> 35<\/b>, 353\u2013363 (2015).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Ge, J. et al. Combined exposure to formaldehyde and PM2. 5: Hematopoietic toxicity and molecular mechanism in mice. Environ. Int.<\/i> 144<\/b>, 106050 (2020).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Kaushansky, K. Lineage-specific hematopoietic growth factors. N. Engl. J. Med.<\/i> 354<\/b>, 2034\u20132045 (2006).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Chavakis, T., Mitroulis, I. & Hajishengallis, G. Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation. Nat. Immunol.<\/i> 20<\/b>, 802\u2013811 (2019).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Ogawa, M. Differentiation and proliferation of hematopoietic stem cells. Blood<\/i> 81<\/b>, 2844\u20132853 (1993).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Wright, D. E., Wagers, A. J., Gulati, A. P., Johnson, F. L. & Weissman, I. L. Physiological migration of hematopoietic stem and progenitor cells. Science<\/i> 294<\/b>, 1933\u20131936 (2001).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Khurshid, S. S., Siegel, J. A. & Kinney, K. A. Indoor particulate reactive oxygen species concentrations. Environ. Res.<\/i> 132<\/b>, 46\u201353 (2014).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Daher, N. et al. Oxidative potential and chemical speciation of size-resolved particulate matter (PM) at near-freeway and urban background sites in the greater Beirut area. Sci. Total Environ.<\/i> 470<\/b>, 417\u2013426 (2014).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Bhattarai, G., Sim, H.-J., So, H.-S., Lee, J.-C. & Kook, S.-H. Exposure of newborns to atmospherically relevant artificial particulate matter induces hematopoietic stem cell senescence. J. Hazard. Mater.<\/i> 452<\/b>, 131293 (2023).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Wang, Y. et al. PM2. 5 Increases Systemic Inflammatory Cells and Associated Disease Risks by Inducing NRF2-Dependent Myeloid-Biased Hematopoiesis in Adult Male Mice. Environ. Sci. Technol.<\/i> 57<\/b>, 7924\u20137937 (2023).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Muller-Sieburg, C. E., Cho, R. H., Karlsson, L., Huang, J.-F. & Sieburg, H. B. Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness. Blood<\/i> 103<\/b>, 4111\u20134118 (2004).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Liu, L.-L. et al. Effects of Long-Term Exposure to PM2. 5 on Oxidative Stress Injury and Expression of Inflammatory Factors, NF-\u03baB p65 and Cx43 in Bone Marrow of Mice. 10<\/b>, 747286 (2022).<\/p>\n<\/li>\n

  • \n

    Cui, Y. et al. Ambient fine particulate matter suppresses in vivo proliferation of bone marrow stem cells through reactive oxygen species formation. PLoS One<\/i> 10<\/b>, e0127309 (2015).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Godri, K. J. et al. Particulate oxidative burden associated with firework activity. Environ. Sci. Technol.<\/i> 44<\/b>, 8295\u20138301 (2010).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Banaclocha, M. M., Hernandez, A. I., Mart\u0131nez, N. & Ferrandiz, M. L. N-acetylcysteine protects against age-related increase in oxidized proteins in mouse synaptic mitochondria. Brain Res.<\/i> 762<\/b>, 256\u2013258 (1997).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Voghel, G. et al. Chronic treatment with N-acetyl-cystein delays cellular senescence in endothelial cells isolated from a subgroup of atherosclerotic patients. Mech. Ageing Dev.<\/i> 129<\/b>, 261\u2013270 (2008).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Samper, E. et al. Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells. Blood, J. Am. Soc. Hematol.<\/i> 99<\/b>, 2767\u20132775 (2002).<\/p>\n

    CAS<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Chang-Chien, J. et al. Particulate matter causes telomere shortening and increase in cellular senescence markers in human lung epithelial cells. Ecotoxicol. Environ. Saf.<\/i> 222<\/b>, 112484 (2021).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Park, B. et al. In International Forum of Allergy & Rhinology, Vol. 12 1424 (Wiley-Blackwell, 2022).<\/p>\n<\/li>\n

  • \n

    Tsai, J. J. et al. Nrf2 regulates haematopoietic stem cell function. Nat. Cell Biol.<\/i> 15<\/b>, 309\u2013316 (2013).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Dai, X. et al. Nrf2: redox and metabolic regulator of stem cell state and function. Trends Mol. Med<\/i> 26<\/b>, 185\u2013200 (2020).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Wang, Y. et al. Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells. Free Radic. Biol. Med<\/i> 48<\/b>, 348\u2013356 (2010).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Wu, F. & Zhang, J. The involvement of Nox4 in fine particulate matter exposure-induced cardiac injury in mice. J. Toxicological Sci.<\/i> 43<\/b>, 171\u2013181 (2018).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Ito, K. et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat. Med.<\/i> 12<\/b>, 446\u2013451 (2006).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Iwasa, H., Han, J. & Ishikawa, F. Mitogen\u2010activated protein kinase p38 defines the common senescence\u2010signalling pathway. Genes Cells<\/i> 8<\/b>, 131\u2013144 (2003).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Ma, Y. et al. Cadmium exposure triggers osteoporosis in duck via P2X7\/PI3K\/AKT-mediated osteoblast and osteoclast differentiation. Sci. Total Environ.<\/i> 750<\/b>, 141638 (2021).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Saha, H., Mukherjee, B., Bindhani, B. & Ray, M. R. Changes in RANKL and osteoprotegerin expression after chronic exposure to indoor air pollution as a result of cooking with biomass fuel. J. Appl Toxicol.<\/i> 36<\/b>, 969\u2013976 (2016).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Abu-Elmagd, M. et al. Evaluation of the effects of airborne particulate matter on bone marrow-mesenchymal stem cells (BM-MSCs): cellular, molecular and systems biological approaches. Int. J. Environ. Res. Public Health<\/i> 14<\/b>, 440 (2017).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Altekruse, S. SEER cancer statistics review, 1975\u20132007. http:\/\/seer.cancer.gov\/csr\/1975_2007\/results_merged\/sect_13_leukemia.pdf<\/a> (2009).<\/p>\n<\/li>\n

  • \n

    Humphries, F., Yang, S., Wang, B. & Moynagh, P. N. RIP kinases: key decision makers in cell death and innate immunity. Cell Death Differ.<\/i> 22<\/b>, 225\u2013236 (2015).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Lee, M.-S. et al. Oxidative stress and systemic inflammation as modifiers of cardiac autonomic responses to particulate air pollution. Int. J. Cardiol.<\/i> 176<\/b>, 166\u2013170 (2014).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Corsini, E. et al. Comparison of wood smoke PM2. 5 obtained from the combustion of FIR and beech pellets on inflammation and DNA damage in A549 and THP-1 human cell lines. Arch. Toxicol.<\/i> 87<\/b>, 2187\u20132199 (2013).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Ostro, B. et al. Chronic PM2. 5 exposure and inflammation: determining sensitive subgroups in mid-life women. Environ. Res.<\/i> 132<\/b>, 168\u2013175 (2014).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Jin, X., Su, R., Li, R., Cheng, L. & Li, Z. Crucial role of pro-inflammatory cytokines from respiratory tract upon PM2. 5 exposure in causing the BMSCs differentiation in cells and animals. Oncotarget<\/i> 9<\/b>, 1745 (2018).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Lambeth, J. D. NOX enzymes and the biology of reactive oxygen. Nat. Rev. Immunol.<\/i> 4<\/b>, 181\u2013189 (2004).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Jin, X. et al. Amelioration of particulate matter-induced oxidative damage by vitamin C and quercetin in human bronchial epithelial cells. Chemosphere<\/i> 144<\/b>, 459\u2013466 (2016).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Manz, M. G. & Boettcher, S. Emergency granulopoiesis. Nat. Rev. Immunol.<\/i> 14<\/b>, 302\u2013314 (2014).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Jacobsen, S. E. W. & Nerlov, C. Haematopoiesis in the era of advanced single-cell technologies. Nat. Cell Biol.<\/i> 21<\/b>, 2\u20138 (2019).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Organization, W. H. Ambient air pollution: A global assessment of exposure and burden of disease. (2016).<\/p>\n<\/li>\n

  • \n

    Ferrucci, L. & Balducci, L. In Seminars in hematology, Vol. 45 242\u2013249 (Elsevier, 2008).<\/p>\n<\/li>\n

  • \n

    Kido, T. et al. Particulate matter induces translocation of IL-6 from the lung to the systemic circulation. Am. J. Respir. Cell Mol. Biol.<\/i> 44<\/b>, 197\u2013204 (2011).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Wardoyo, A. Y., Juswono, U. P. & Noor, J. A. How exposure to ultrafine and fine particles of car smoke can alter erythrocyte forms of male mice. Pol. J. Environ. Stud.<\/i> 28<\/b>, 2901 (2019).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Lavigne, \u00c9. et al. Maternal exposure to ambient air pollution and risk of early childhood cancers: a population-based study in Ontario, Canada. Environ. Int.<\/i> 100<\/b>, 139\u2013147 (2017).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Hvidtfeldt, U. A. et al. Residential exposure to PM2. 5 components and risk of childhood non-hodgkin lymphoma in Denmark: a nationwide register-based case-control Study. Int. J. Environ. Res. Public Health<\/i> 17<\/b>, 8949 (2020).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Sanchez-Guerra, M. et al. Effects of particulate matter exposure on blood 5-hydroxymethylation: results from the Beijing truck driver air pollution study. Epigenetics<\/i> 10<\/b>, 633\u2013642 (2015).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Cortessis, V. K. et al. Environmental epigenetics: prospects for studying epigenetic mediation of exposure\u2013response relationships. Hum. Genet.<\/i> 131<\/b>, 1565\u20131589 (2012).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Hou, L., Zhang, X., Wang, D. & Baccarelli, A. Environmental chemical exposures and human epigenetics. Int. J. Epidemiol.<\/i> 41<\/b>, 79\u2013105 (2012).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Madakashira, B. P. & Sadler, K. C. DNA methylation, nuclear organization, and cancer. Front. Genet.<\/i> 8<\/b>, 76 (2017).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Koch, A. et al. Analysis of DNA methylation in cancer: location revisited. Nat. Rev. Clin. Oncol.<\/i> 15<\/b>, 459\u2013466 (2018).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Zhang, Z. et al. Long-term exposure to ambient particulate matter (PM2. 5) is associated with platelet counts in adults. Environ. Pollut.<\/i> 240<\/b>, 432\u2013439 (2018).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Robertson, S. & Miller, M. R. Ambient air pollution and thrombosis. Part. Fibre Toxicol.<\/i> 15<\/b>, 1\u201316 (2018).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Brook, R. D. et al. Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation<\/i> 121<\/b>, 2331\u20132378 (2010).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Liang, S. et al. Repeat dose exposure of PM2. 5 triggers the disseminated intravascular coagulation (DIC) in SD rats. Sci. Total Environ.<\/i> 663<\/b>, 245\u2013253 (2019).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    R\u00fcckerl, R. et al. Associations between ambient air pollution and blood markers of inflammation and coagulation\/fibrinolysis in susceptible populations. Environ. Int.<\/i> 70<\/b>, 32\u201349 (2014).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Hajat, A. et al. Long-term exposure to air pollution and markers of inflammation, coagulation, and endothelial activation: a repeat-measures analysis in the Multi-Ethnic Study of Atherosclerosis (MESA). Epidemiol. (Camb., Mass.)<\/i> 26<\/b>, 310 (2015).<\/p>\n

    Article<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Hystad, P. et al. Associations of outdoor fine particulate air pollution and cardiovascular disease in 157 436 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study. Lancet Planet Health<\/i> 4<\/b>, e235\u2013e245 (2020).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Gao, X. et al. Short-term exposure to PM2. 5 components and renal health: Findings from the Veterans Affairs Normative Aging Study. J. Hazard Mater.<\/i> 420<\/b>, 126557 (2021).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Liu, L., Zhang, Y., Yang, Z., Luo, S. & Zhang, Y. Long-term exposure to fine particulate constituents and cardiovascular diseases in Chinese adults. J. Hazard Mater.<\/i> 416<\/b>, 126051 (2021).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Lao, X. Q. et al. Long-term exposure to ambient fine particulate matter (PM 2.5) and incident type 2 diabetes: a longitudinal cohort study. Diabetologia<\/i> 62<\/b>, 759\u2013769 (2019).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Gilcrease, G. W. et al. Is air pollution affecting the disease activity in patients with systemic lupus erythematosus? State of the art and a systematic literature review. Eur. J. Rheumatol.<\/i> 7<\/b>, 31 (2020).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Pun, V. C., Kazemiparkouhi, F., Manjourides, J. & Suh, H. H. Long-term PM2. 5 exposure and respiratory, cancer, and cardiovascular mortality in older US adults. Am. J. Epidemiol.<\/i> 186<\/b>, 961\u2013969 (2017).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Essers, M. A. et al. IFN\u03b1 activates dormant haematopoietic stem cells in vivo. Nature<\/i> 458<\/b>, 904\u2013908 (2009).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Walter, D. et al. Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature<\/i> 520<\/b>, 549\u2013552 (2015).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Pietras, E. M. et al. Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal. Nat. Cell Biol.<\/i> 18<\/b>, 607\u2013618 (2016).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Pronk, C. J., Veiby, O. P., Bryder, D. & Jacobsen, S. E. W. Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors. J. Exp. Med.<\/i> 208<\/b>, 1563\u20131570 (2011).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Makris, S. et al. Immune function and dysfunction are determined by lymphoid tissue efficacy. Dis. Model. Mech.<\/i> 15<\/b>, dmm049256 (2022).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Jung, E. M. et al. Association between prenatal exposure to PM2. 5 and the increased risk of specified infant mortality in South Korea. Environ. Int<\/i> 144<\/b>, 105997 (2020).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Ortigoza, A. et al. Association between ambient PM2\u00b7 5 and under-5, infant, and child mortality in Latin America, 2010\u201315: a longitudinal analysis. 5<\/b>, S16 (2021).<\/p>\n<\/li>\n

  • \n

    Bo, Y. et al. Associations of reduced ambient PM2. 5 level with lower plasma glucose concentration and decreased risk of type 2 diabetes in adults: a longitudinal cohort study. Am. J. Epidemiol.<\/i> 190<\/b>, 2148\u20132157 (2021).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Hayes, R. B. et al. PM2. 5 air pollution and cause-specific cardiovascular disease mortality. Int J. Epidemiol.<\/i> 49<\/b>, 25\u201335 (2020).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Bowe, B. et al. Particulate matter air pollution and the risk of incident CKD and progression to ESRD. J. Am. Soc. Nephrol.<\/i> 29<\/b>, 218 (2018).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Lee, J.-T. J. C. & Pediatrics, E. Review of epidemiological studies on air pollution and health effects in children. Clin. Exp. Pediatr.<\/i> 64<\/b>, 3 (2021).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Li, G., Li, L., Liu, D., Qin, J. & Zhu, H. J. S. R. Effect of PM2. 5 pollution on perinatal mortality in China. Sci. Rep.<\/i> 11<\/b>, 7596 (2021).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Alman, B. L. et al. Associations between PM2. 5 and risk of preterm birth among liveborn infants. Ann. Epidemiol.<\/i> 39<\/b>, 46\u201353 (2019).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Tao, R.-j et al. PM2. 5 compromises antiviral immunity in influenza infection by inhibiting activation of NLRP3 inflammasome and expression of interferon-\u03b2. Mol. Immunol.<\/i> 125<\/b>, 178\u2013186 (2020).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Prada, D., L\u00f3pez, G., Solleiro-Villavicencio, H., Garcia-Cuellar, C. & Baccarelli, A. A. Molecular and cellular mechanisms linking air pollution and bone damage. Environ. Res<\/i> 185<\/b>, 109465 (2020).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Qiu, Y.-N. et al. PM2. 5 induces liver fibrosis via triggering ROS-mediated mitophagy. Ecotoxicol. Environ. Saf.<\/i> 167<\/b>, 178\u2013187 (2019).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Li, R., Zhou, R. & Zhang, J. Function of PM2. 5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases. Oncol. Lett.<\/i> 15<\/b>, 7506\u20137514 (2018).<\/p>\n

    PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Chen, S. et al. Effect of PM2. 5 on macrosomia in China: A nationwide prospective cohort study. Pediatr. Obes.<\/i> 15<\/b>, e12584 (2020).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    N\u00e4\u00e4v, \u00c5. et al. Urban PM2. 5 induces cellular toxicity, hormone dysregulation, oxidative damage, inflammation, and mitochondrial interference in the HRT8 trophoblast cell line. Front Endocrinol. (Lausanne)<\/i> 11<\/b>, 75 (2020).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Zhou, S. et al. Ovarian dysfunction induced by chronic whole\u2010body PM2. 5 exposure. Small<\/i> 16<\/b>, 2000845 (2020).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    int\/mediacentre\/factsheets\/fs313\/en\/, W.H.O.J.R.f.W.H.O.A.f.h.w.w. Ambient (outdoor) air quality and health. 2018 (2016).<\/p>\n<\/li>\n

  • \n

    Wu, J. et al. The association between long-term exposure to ambient air pollution and bone strength in China. J. Clin. Endocrinol. Metab.<\/i> 106<\/b>, e5097\u2013e5108 (2021).<\/p>\n

    PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Yang, Y. et al. Ambient air pollution, bone mineral density and osteoporosis: results from a national population-based cohort study. Chemosphere<\/i> 310<\/b>, 136871 (2023).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Qiao, D. et al. Long-term exposure to air pollution might increase prevalence of osteoporosis in Chinese rural population. Environ. Res<\/i> 183<\/b>, 109264 (2020).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Yu, P. et al. Associations between long-term exposure to PM2. 5 and site-specific cancer mortality: A nationwide study in Brazil between 2010 and 2018. Environ. Pollut.<\/i> 302<\/b>, 119070 (2022).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Morales-Ancajima, V. C. et al. Increased outdoor PM2. 5 concentration is associated with moderate\/severe anemia in children aged 6\u201359 months in Lima, Peru. J. Environ. Public Health<\/i> 2019<\/b>, 6127845 (2019).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Honda, T., Pun, V. C., Manjourides, J. & Suh, H. Anemia prevalence and hemoglobin levels are associated with long-term exposure to air pollution in an older population. Environ. Int.<\/i> 101<\/b>, 125\u2013132 (2017).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Visani, G. et al. Environmental nanoparticles are significantly over-expressed in acute myeloid leukemia. Leuk. Res.<\/i> 50<\/b>, 50\u201356 (2016).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Giannoni, P. et al. Chronic lymphocytic leukemia cells impair osteoblastogenesis and promote osteoclastogenesis: role of TNF\u03b1, IL-6 and IL-11 cytokines. Haematologica<\/i> 106<\/b>, 2598 (2021).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Wells, A. et al. Systemic IL-6 effector response in mediating systemic bone loss following inhalation of organic dust. J. Interferon Cytokine Res.<\/i> 37<\/b>, 9\u201319 (2017).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Calder\u00f3n-Garcidue\u00f1as, L. et al. Exposure to urban air pollution and bone health in clinically healthy six-year-old children. Arh. Hig. Rada Toksikol.<\/i> 64<\/b>, 23\u201323 (2013).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Chen, Y. et al. Probucol protects circulating endothelial progenitor cells from ambient PM2. 5 damage via inhibition of reactive oxygen species and inflammatory cytokine production in vivo. Exp. Ther. Med.<\/i> 16<\/b>, 4322\u20134328 (2018).<\/p>\n

    CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Liberda, E. N. et al. Exposure to inhaled nickel nanoparticles causes a reduction in number and function of bone marrow endothelial progenitor cells. Inhal. Toxicol.<\/i> 22<\/b>, 95\u201399 (2010).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Haberzettl, P. et al. Exposure to ambient air fine particulate matter prevents VEGF-induced mobilization of endothelial progenitor cells from the bone marrow. Environ. Health Perspect.<\/i> 120<\/b>, 848\u2013856 (2012).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    O\u2019Toole, T. E. et al. Episodic exposure to fine particulate air pollution decreases circulating levels of endothelial progenitor cells. Circ. Res<\/i> 107<\/b>, 200\u2013203 (2010).<\/p>\n

    Article<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Yamaguchi, M. & Kashiwakura, I. Role of reactive oxygen species in the radiation response of human hematopoietic stem\/progenitor cells. PLoS One<\/i> 8<\/b>, e70503 (2013).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Rodrigues-Moreira, S. et al. Low-dose irradiation promotes persistent oxidative stress and decreases self-renewal in hematopoietic stem cells. Cell Rep.<\/i> 20<\/b>, 3199\u20133211 (2017).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Eliasson, P. et al. Hypoxia mediates low cell-cycle activity and increases the proportion of long-term\u2013reconstituting hematopoietic stem cells during in vitro culture. Exp. Hematol.<\/i> 38<\/b>, 301\u2013310 (2010).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Ito, K. et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature<\/i> 431<\/b>, 997\u20131002 (2004).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Renzi, M. et al. Short-term exposure to PM2. 5 and risk of venous thromboembolism: A case-crossover study. Thromb. Res<\/i> 190<\/b>, 52\u201357 (2020).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Cliff, R. et al. Effect of diesel exhaust inhalation on blood markers of inflammation and neurotoxicity: a controlled, blinded crossover study. Inhal. Toxicol.<\/i> 28<\/b>, 145\u2013153 (2016).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Orona, N. S. et al. Acute exposure to Buenos Aires air particles (UAP-BA) induces local and systemic inflammatory response in middle-aged mice: A time course study. Environ. Pollut.<\/i> 208<\/b>, 261\u2013270 (2016).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n

  • \n

    Park, S.-R. et al. The impact of fine particulate matter (PM) on various beneficial functions of human endometrial stem cells through its key regulator SERPINB2. Exp. Mol. Med<\/i> 53<\/b>, 1850\u20131865 (2021).<\/p>\n

    Article<\/a> 
    \n     CAS<\/a> 
    \n     PubMed<\/a> 
    \n     PubMed Central<\/a> 
    \n
    \n Google Scholar<\/a> \n <\/p>\n<\/li>\n