{"id":441996,"date":"2024-01-03T12:08:00","date_gmt":"2024-01-03T17:08:00","guid":{"rendered":"https:\/\/platohealth.ai\/pfizer-wins-canadian-ok-for-hemophilia-treatment-its-first-gene-therapy\/"},"modified":"2024-01-03T12:31:07","modified_gmt":"2024-01-03T17:31:07","slug":"pfizer-wins-canadian-ok-for-hemophilia-treatment-its-first-gene-therapy","status":"publish","type":"post","link":"https:\/\/platohealth.ai\/pfizer-wins-canadian-ok-for-hemophilia-treatment-its-first-gene-therapy\/","title":{"rendered":"Pfizer wins Canadian OK for hemophilia treatment, its first gene therapy","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"
Hemophilia and other blood disorders like sickle cell disease and beta thalassemia have drawn intense investment from genetic medicine developers. in December, the FDA approved two such treatments for sickle cell, clearing Vertex Pharmaceuticals\u2019 gene editing drug Casgevy and Bluebird bio\u2019s viral vector therapy Lyfgenia.<\/p>\n
In hemophilia B \u2014 the more uncommon of the two types of the bleeding disorder \u2014 Hemgenix has been on the U.S. market<\/a> since November 2022, where it has a list price of $3.5 million. Australia-based CSL, which licensed the treatment from gene therapy pioneer UniQure<\/a>, hasn\u2019t broken out sales revenue from Hemgenix in its most recent financial reports.<\/p>\n In Canada, the two companies will be competing to treat around 700 people<\/a>, some of whom may be successfully treated with factor protein replacements and might not seek out gene therapy.<\/p>\n Being on the market first is an advantage for drugmakers, and even more so for gene therapies intended to be one-time treatments. Early last year, when Pfizer announced its strategic shift, a company spokesperson said Pfizer wanted to \u201cfocus on programs where our innovation and investments are differentiated and where we are best positioned to generate high-impact medicines and vaccines.\u201d<\/p>\n Those moves included focusing on genetic medicine tools other than viral vectors, putting a gene therapy facility up for sale, and in July selling off some programs and technology to AstraZeneca\u2019s Alexion rare disease unit for up to $1 billion<\/a>.<\/p>\n The bid to reduce its gene therapy spending came amid a tumultuous year for Pfizer, which announced plans to cut costs by around $4 billion<\/a> in 2024, primarily from research and development, as plummeting sales of COVID-19 vaccines and drugs caused revenues to come in below the company\u2019s expectations.<\/p>\n Dive Brief: Canada\u2019s health regulators have approved Pfizer\u2019s gene therapy for hemophilia B, the company said Wednesday, making it the first time the drugmaker has received regulatory clearance for such a genetic medicine. The gene therapy, which Pfizer licensed nine years ago from Spark Therapeutics, will compete with CSL\u2019s Hemgenix, a similar treatment that gained […]<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":2,"featured_media":441999,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[50],"tags":[],"acf":[],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts\/441996"}],"collection":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/comments?post=441996"}],"version-history":[{"count":1,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts\/441996\/revisions"}],"predecessor-version":[{"id":441998,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts\/441996\/revisions\/441998"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/media\/441999"}],"wp:attachment":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/media?parent=441996"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/categories?post=441996"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/tags?post=441996"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n