{"id":403924,"date":"2023-12-29T12:11:54","date_gmt":"2023-12-29T17:11:54","guid":{"rendered":"https:\/\/platohealth.ai\/novel-solution-for-pichia-pastoris-enzyme-production-platform\/"},"modified":"2023-12-30T23:03:11","modified_gmt":"2023-12-31T04:03:11","slug":"novel-solution-for-pichia-pastoris-enzyme-production-platform","status":"publish","type":"post","link":"https:\/\/platohealth.ai\/novel-solution-for-pichia-pastoris-enzyme-production-platform\/","title":{"rendered":"Novel solution for Pichia pastoris enzyme production platform","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"

The demand for industrial enzymes is continually rising, driven by the growing need to shift towards more sustainable industrial processes. Our research outlines a novel approach in enzyme production, harnessing the untapped potential of cyanobacterial biomass within the P. pastoris<\/em> platform. Group Leader, Dr. Schieder, highlights the nature of the study, stating, \u201cOur work reveals the potential of cyanobacterial biorefineries to support enzyme production.\u201d<\/p>\n

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Credit: Dr. Doris Schieder, Chair of Chemistry of Biogenic Resources, Technical University of Munich, Campus Straubing for Biotechnology and Sustainability, Germany<\/p>\n

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The demand for industrial enzymes is continually rising, driven by the growing need to shift towards more sustainable industrial processes. Our research outlines a novel approach in enzyme production, harnessing the untapped potential of cyanobacterial biomass within the P. pastoris<\/em> platform. Group Leader, Dr. Schieder, highlights the nature of the study, stating, \u201cOur work reveals the potential of cyanobacterial biorefineries to support enzyme production.\u201d<\/p>\n

This achievement stems from an extensive multi-field approach. We characterized and expanded a combinatorial library, streamlining P. pastoris<\/em> engineering for enhanced efficiency. Rigorous screening of these libraries yielded potent enzyme-producing strains enabling the development of a fed-batch strategy for efficient AppA E. coli<\/em> phytase expression. A key element is the successful utilization of Nostoc sp. De1 biomass hydrolysate as substrate for fermentation, presenting a viable and sustainable alternative to conventional feedstock. Korbinian Sinzinger underscores the importance of this research, stating, \u201cOur findings demonstrate that the extended P. pastoris <\/em>toolkit not only generates high-performing producer strains but also offers a greener pathway for enzyme expression, addressing the critical need for sustainable biobased production.\u201d<\/p>\n

See the article:<\/strong><\/p>\n

DOI<\/strong><\/p>\n

https:\/\/doi.org\/10.1016\/j.jobab.2023.12.005<\/p>\n

Original Source URL<\/strong><\/p>\n

https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2369969823000798<\/p>\n

Journal<\/strong><\/p>\n

Journal of Bioresources and Bioproducts<\/em><\/p>\n

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Journal<\/h4>\n

Journal of Bioresources and Bioproducts<\/p>\n<\/p><\/div>\n

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DOI<\/h4>\n

10.1016\/j.jobab.2023.12.005 <\/i><\/p>\n<\/p><\/div>\n

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Method of Research<\/h4>\n

Experimental study<\/p>\n<\/div>\n

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Subject of Research<\/h4>\n

Cells<\/p>\n<\/p><\/div>\n

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Article Title<\/h4>\n

The Pichia pastoris Enzyme Production Platform: from Combinatorial Library Screening to Bench-Top Fermentation on Residual Cyanobacterial Biomass<\/p>\n<\/p><\/div>\n

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Article Publication Date<\/h4>\n

26-Dec-2023<\/p>\n<\/p><\/div>\n

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COI Statement<\/h4>\n

There are no conflicts to declare.<\/p>\n<\/p><\/div>\n<\/div>\n<\/div>\n<\/div>\n