{"id":389113,"date":"2023-12-21T01:00:00","date_gmt":"2023-12-21T06:00:00","guid":{"rendered":"https:\/\/platohealth.ai\/the-cause-of-alzheimers-may-be-coming-from-inside-your-mouth\/"},"modified":"2023-12-21T02:25:58","modified_gmt":"2023-12-21T07:25:58","slug":"the-cause-of-alzheimers-may-be-coming-from-inside-your-mouth","status":"publish","type":"post","link":"https:\/\/platohealth.ai\/the-cause-of-alzheimers-may-be-coming-from-inside-your-mouth\/","title":{"rendered":"The Cause of Alzheimer\u2019s May Be Coming From Inside Your Mouth","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"

The Cause of Alzheimer\u2019s May Be Coming From Inside Your Mouth<\/a><\/h3>\n

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\n\t\t\t\t\t\t\t\tPosted on December 21, 2023<\/a><\/span> Updated on December 18, 2023<\/a><\/span>\t\t\t<\/span>\n\t\t<\/p>\n

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In recent years, a growing number of scientific studies have backed an alarming hypothesis: Alzheimer\u2019s<\/a> disease isn\u2019t just a disease, it\u2019s an infection<\/a>.<\/p>\n

While the exact mechanisms of this infection are something researchers are still trying to isolate<\/a>, numerous studies suggest the deadly spread<\/a> of Alzheimer\u2019s goes way beyond<\/a> what we used to think.<\/p>\n

One such study, published in 2019, suggested what could be one of the most definitive leads yet for a bacterial culprit behind Alzheimer\u2019s, and it comes from a somewhat unexpected quarter: gum disease.<\/p>\n

In a paper led by senior author Jan Potempa, a microbiologist from the University of Louisville, researchers reported the discovery of Porphyromonas gingivalis<\/em><\/a> \u2013 the pathogen behind chronic periodontitis<\/a> (aka gum disease) \u2013 in the brains of deceased Alzheimer\u2019s patients.<\/p>\n

\"530P. gingivalis\u2019 gingipains (red) among neurons in the brain of a patient with Alzheimer\u2019s. (Cortexyme)<\/p>\n

It wasn\u2019t the first time the two factors have been linked<\/a>, but the researchers went further.<\/p>\n

In separate experiments with mice, oral infection with the pathogen led to brain colonization by the bacteria, together with increased production of amyloid beta (A\u03b2), the sticky proteins commonly associated with Alzheimer\u2019s.<\/p>\n

The research team, coordinated by pharma startup Cortexyme, which was co-founded by first author Stephen Dominy, wasn\u2019t claiming to have discovered definitive evidence of Alzheimer\u2019s causation.<\/p>\n

But it was clear they thought we had a strong line of investigation here.<\/p>\n

\u201cInfectious agents have been implicated in the development and progression of Alzheimer\u2019s disease before, but the evidence of causation hasn\u2019t been convincing,\u201d Dominy said at the time<\/a>.<\/p>\n

\u201cNow, for the first time, we have solid evidence connecting the intracellular, Gram-negative pathogen, P. gingivalis<\/em>, and Alzheimer\u2019s pathogenesis.\u201d<\/p>\n

In addition, the team identified toxic enzymes called gingipains secreted by the bacteria in the brains of Alzheimer\u2019s patients, which correlated with two separate markers of the disease: the tau protein, and a protein tag called ubiquitin.<\/p>\n

But even more compellingly, the team identified these toxic gingipains in the brains of deceased people who were never diagnosed with Alzheimer\u2019s.<\/p>\n

That\u2019s important, because while P. gingivalis<\/em> and the disease have been linked before, it\u2019s never been known \u2013 to put it simply \u2013 whether gum disease causes Alzheimers, or whether dementia leads to poor oral care.<\/p>\n

The fact that low levels of gingipains were evident even in people who were never diagnosed with Alzheimer\u2019s could be a smoking gun \u2013 suggesting they might have developed the condition if they had lived longer.<\/p>\n

\u201cOur identification of gingipain antigens in the brains of individuals with AD and also with AD pathology but no diagnosis of dementia argues that brain infection with P. gingivalis<\/em> is not a result of poor dental care following the onset of dementia or a consequence of late-stage disease, but is an early event that can explain the pathology found in middle-aged individuals before cognitive decline,\u201d the authors explained in their paper<\/a>.<\/p>\n

Further, a compound formulated by the company called COR388, showed in experiments with mice that it could reduce bacterial load of an established P. gingivalis<\/em> brain infection, while also reducing amyloid-beta production and neuroinflammation.<\/p>\n

We\u2019ll have to wait and see what future research will uncover about this link, but the research community is cautiously optimistic.<\/p>\n

\u201cDrugs targeting the bacteria\u2019s toxic proteins have so far only shown benefit in mice, yet with no new dementia treatments in over 15 years it\u2019s important that we test as many approaches as possible to tackle diseases like Alzheimer\u2019s,\u201d chief scientific officer David Reynolds from Alzheimer\u2019s Research commented in a statement<\/a>.<\/p>\n

The findings were reported in Science Advances<\/em><\/a>.<\/p>\n

An earlier version of this story was published in January 2019.<\/em><\/p>\n

Source : 1<\/a><\/p>\n