{"id":353535,"date":"2023-11-21T19:00:00","date_gmt":"2023-11-22T00:00:00","guid":{"rendered":"https:\/\/platohealth.ai\/sequential-vs-myeloablative-vs-reduced-intensity-conditioning-for-patients-with-myelodysplastic-syndromes-with-an-excess-of-blasts-at-time-of-allogeneic-haematopoietic-cell-transplantation-a-retrospe\/"},"modified":"2023-11-22T12:30:14","modified_gmt":"2023-11-22T17:30:14","slug":"sequential-vs-myeloablative-vs-reduced-intensity-conditioning-for-patients-with-myelodysplastic-syndromes-with-an-excess-of-blasts-at-time-of-allogeneic-haematopoietic-cell-transplantation-a-retrospe","status":"publish","type":"post","link":"https:\/\/platohealth.ai\/sequential-vs-myeloablative-vs-reduced-intensity-conditioning-for-patients-with-myelodysplastic-syndromes-with-an-excess-of-blasts-at-time-of-allogeneic-haematopoietic-cell-transplantation-a-retrospe\/","title":{"rendered":"Sequential vs myeloablative vs reduced intensity conditioning for patients with myelodysplastic syndromes with an excess of blasts at time of allogeneic haematopoietic cell transplantation: a retrospective study by the chronic malignancies working party of the EBMT – Bone Marrow Transplantation","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"
Garcia\u2010Manero G, Chien KS, Montalban\u2010Bravo G. Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management. Am J Hematol. 2020;95:1399\u2013420.<\/p>\n
Article<\/a>\u00a0 Kr\u00f6ger N. Induction, bridging, or straight ahead: the ongoing dilemma of allografting in advanced myelodysplastic syndrome. Biol Blood Marrow Transpl. 2019;25:e247\u20139.<\/p>\n Article<\/a>\u00a0 Saure C, Schroeder T, Zohren F, Groten A, Bruns I, Czibere A, et al. Upfront allogeneic blood stem cell transplantation for patients with high-risk myelodysplastic syndrome or secondary acute myeloid leukemia using a FLAMSA-based high-dose sequential conditioning regimen. Biol Blood Marrow Transpl. 2012;18:466\u201372.<\/p>\n Article<\/a>\u00a0 Schmid C, Schleuning M, Ledderose G, Tischer J, Kolb H-J. Sequential regimen of chemotherapy, reduced-intensity conditioning for allogeneic stem-cell transplantation, and prophylactic donor lymphocyte transfusion in high-risk acute myeloid leukemia and myelodysplastic syndrome. J Clin Oncol. 2005;23:5675\u201387.<\/p>\n Article<\/a>\u00a0 Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood. 1997;89:2079\u201388.<\/p>\n Article<\/a>\u00a0 Arber DA, Orazi A, Hasserjian R, Borowitz MJ, Beau MM, Bloomfield CD, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127:2391\u2013406.<\/p>\n Article<\/a>\u00a0 Greenberg PL, Tuechler H, Schanz J, Sanz G, Garcia-Manero G, Sol\u00e9 F, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood. 2012;120:2454\u201365.<\/p>\n Article<\/a>\u00a0 Bacigalupo A, Ballen K, Rizzo D, Giralt S, Lazarus H, Ho V, et al. Defining the intensity of conditioning regimens: working definitions. Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl. 2009;15:1628\u201333.<\/p>\n Article<\/a>\u00a0 Schemper M, Smith TL. A note on quantifying follow-up in studies of failure time. Control Clin Trials. 1996;17:343\u20136.<\/p>\n Article<\/a>\u00a0 Scott BL, Pasquini MC, Logan BR, Wu J, Devine SM, Porter DL, et al. Myeloablative versus reduced-intensity hematopoietic cell transplantation for acute myeloid leukemia and myelodysplastic syndromes. J Clin Oncol. 2017;35:1154\u201361.<\/p>\n Article<\/a>\u00a0 Kr\u00f6ger N, Iacobelli S, Franke G-N, Platzbecker U, Uddin R, H\u00fcbel K, et al. Dose-reduced versus standard conditioning followed by allogeneic stem-cell transplantation for patients with myelodysplastic syndrome: a prospective randomized Phase III study of the EBMT (RICMAC Trial). J Clin Oncol. 2017;35:2157\u201364.<\/p>\n Article<\/a>\u00a0 Craddock C, Jackson A, Loke J, Siddique S, Hodgkinson A, Mason J, et al. Augmented reduced-intensity regimen does not improve postallogeneic transplant outcomes in acute myeloid leukemia. J Clin Oncol. 2021;39:768\u201378.<\/p>\n Article<\/a>\u00a0 Hourigan CS, Dillon LW, Gui G, Logan BR, Fei M, Ghannam J, et al. Impact of conditioning intensity of allogeneic transplantation for acute myeloid leukemia with genomic evidence of residual disease. J Clin Oncol. 2020;38:1273\u201383.<\/p>\n Article<\/a>\u00a0 Christopeit M, Badbaran A, Alawi M, Zabelina T, Zeck G, Wolschke C, et al. Correlation of somatic mutations with outcome after FLAMSA-busulfan sequential conditioning and allogeneic stem cell transplantation in patients with myelodysplastic syndromes. Eur J Haematol. 2016;97:288\u201396.<\/p>\n Article<\/a>\u00a0 Ciurea SO, Chilkulwar A, Saliba RM, Chen J, Rondon G, Patel KP, et al. Prognostic factors influencing survival after allogeneic transplantation for AML\/MDS patients with TP53 mutations. Blood. 2018;131:2989\u201392.<\/p>\n Article<\/a>\u00a0 Lindsley RC, Saber W, Mar BG, Redd R, Wang T, Haagenson MD, et al. Prognostic mutations in myelodysplastic syndrome after stem-cell transplantation. N. Engl J Med. 2017;376:536\u201347.<\/p>\n Article<\/a>\u00a0 Forcade E, Chevret S, Finke J, Ehninger G, Beelen D, et al. Impact of in vivo T-cell depletion in patients with myelodysplastic syndromes undergoing allogeneic hematopoietic stem cell transplant: a registry study from the Chronic Malignancies Working Party of the EBMT. Bone Marrow Transpl. 2022;57:768\u201374.<\/p>\n Article<\/a>\u00a0 Garcia\u2010Manero G, Chien KS, Montalban\u2010Bravo G. Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management. Am J Hematol. 2020;95:1399\u2013420. Article\u00a0 PubMed\u00a0 Google Scholar\u00a0 Kr\u00f6ger N. Induction, bridging, or straight ahead: the ongoing dilemma of allografting in advanced myelodysplastic syndrome. Biol Blood Marrow Transpl. 2019;25:e247\u20139. Article\u00a0 Google Scholar\u00a0 Saure C, Schroeder T, Zohren F, Groten […]<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":2,"featured_media":353538,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[51],"tags":[],"acf":[],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts\/353535"}],"collection":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/comments?post=353535"}],"version-history":[{"count":1,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts\/353535\/revisions"}],"predecessor-version":[{"id":353537,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/posts\/353535\/revisions\/353537"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/media\/353538"}],"wp:attachment":[{"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/media?parent=353535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/categories?post=353535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/platohealth.ai\/wp-json\/wp\/v2\/tags?post=353535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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