{"id":350295,"date":"2023-11-20T19:00:00","date_gmt":"2023-11-21T00:00:00","guid":{"rendered":"https:\/\/platohealth.ai\/cyp-screening-for-a-better-terpenoid-world-nature-catalysis\/"},"modified":"2023-11-21T12:30:27","modified_gmt":"2023-11-21T17:30:27","slug":"cyp-screening-for-a-better-terpenoid-world-nature-catalysis","status":"publish","type":"post","link":"https:\/\/platohealth.ai\/cyp-screening-for-a-better-terpenoid-world-nature-catalysis\/","title":{"rendered":"CYP screening for a better terpenoid world – Nature Catalysis","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"
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Diverse cytochrome P450s (CYPs) in nature can modify terpenoid scaffolds toward products with higher structural complexity and chemical diversity, but their discovery remains challenging. Now, an Escherichia coli<\/i> -based gene screening platform enables high-throughput bacterial CYP screening, leading to efficient and diverse terpenoid biosynthesis.<\/p>\n<\/div>\n

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Terpenoids constitute the largest and most diverse group of natural products. With over 110,000 distinct analogues widely distributed in animals, plants, and microbes, they account for a large volume \u2014 approximately 60% \u2014 of known natural products1<\/a>,2<\/a><\/sup>. Terpenoids are used extensively in the agriculture, biofuels, food and even pharmaceutical industries: the latter application is exemplified by artemisinin, a sesquiterpene lactone for malaria treatment, the discovery of which merited the 2015 Nobel Prize in Physiology or Medicine3<\/a><\/sup>. The structural complexity and chemical diversity of terpenoids underscore their broad applications, which, however, also introduce unique challenges in the elucidation of their synthetic pathway and industrial biomanufacturing.<\/p>\n<\/div>\n