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Voltage-gated sodium channel insights outside of pain

DATA GRAPHICS | Discovery & Translation

Researchers link Nav1.7 to osteoarthritis progression and identify a modulator of Nav1.6 for epilepsy

By Danielle Golovin, Senior Biopharma Analyst

January 12, 2024 1:24 AM UTC

Two academic groups have published new information about voltage-gated sodium channels that could expand their therapeutic potential beyond treatment of pain.

So far, almost all of the drug development activity targeting voltage-gated sodium (Nav) channels has been centered on pain relief, and largely focused on the Nav1.7 channel subtype, which is widely considered a master controller of action potential firing in sensory neurons…