Tolerability data will matter more than efficacy in Zepbound vs. Wegovy: a Perspective

ARTICLE | Editor’s Commentary

Lilly quiet on safety as Zepbound beats Wegovy in head-to-head trial

By Stephen Hansen, Director of Biopharma Intelligence

December 5, 2024 12:40 AM UTC

It’s no surprise that Lilly’s Zepbound produced more weight loss than Novo’s Wegovy in a head-to-head trial. Yet-to-be disclosed tolerability data for the drug will be more meaningful in increasing Lilly’s share of the obesity market.

The efficacy result Eli Lilly and Co. (NYSE:LLY) announced on Wednesday was expected, confirming what was clearly evident in the companies’ independently conducted Phase III trials.