ARTICLE | Discovery & Translation
BioCentury’s roundup of translational innovations
By Danielle Golovin, Senior Biopharma Analyst
September 26, 2024 12:50 AM UTC


Stanford University researchers described a method in Nature to relocalize endogenous proteins within subcellular compartments.
The team identified a group of shuttle proteins that can be co-opted using a bifunctional molecule, dubbed targeted relocalization-activating molecules (TRAMs), to re-localize a target protein. The authors then showed it could use nuclear hormone receptors as shuttles to redistribute disease-driving mutant proteins from the cytoplasm to the nucleus…
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- Source: https://www.biocentury.com/article/653662/science-spotlight-targeted-protein-relocalization-rejuvenating-aged-eggs-and-more