ARTICLE | Discovery & Translation
BioCentury’s roundup of translational innovations
By Danielle Golovin, Senior Biopharma Analyst
April 20, 2024 12:58 AM UTC


BioTroy Therapeutics Inc. described a new way that tumor cells evade the immune system.
The company, with collaborators from Fudan University, showed in Cell that ITPRIPL1, a membrane protein of previously unknown function, binds and inhibits CD3ɛ on T cells. In mouse models of various solid tumor types, treatment with an anti-ITPRIPL1 antibody promoted T cell infiltration and reduced tumor growth. The antibody also had therapeutic efficacy against naturally occurring tumors in dogs…
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- Source: https://www.biocentury.com/article/652165/science-spotlight-new-immune-evasion-pathway-plus-bbb-breakdown-mechanism-and-more