ARTICLE | Discovery & Translation
BioCentury’s roundup of translational innovations also includes a study from Amgen and a newco spotlight
By Danielle Golovin, Senior Biopharma Analyst
November 7, 2024 8:30 PM UTC
Researchers from Icahn School of Medicine at Mount Sinai, including Antenna Biotech Inc. co-founder Yi Shi, developed a platform that can display over 20 antibodies, designed to bind multiple conserved and neutralizing epitopes on a pathogen.
The platform, dubbed adaptive multi-epitope targeting with enhanced avidity (AMETA), conjugates bispecific single-domain antibody fragments to a human IgM scaffold. The authors used structure-guided design to make a construct targeting multiple epitopes of SARS-CoV-2 that surpassed monomeric antibody potency over a million-fold…
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- Source: https://www.biocentury.com/article/654097/science-spotlight-multi-epitope-antivirals-metastatic-transition-and-more