ARTICLE | Discovery & Translation
BioCentury’s roundup of translational innovations
By Danielle Golovin, Senior Biopharma Analyst
July 3, 2024 11:52 PM UTC
Researchers reported in Science a zinc finger-based epigenome editor with advantages over a CRISPR-based version of the system, and showed it could durably suppress brain expression of a protein that causes toxic aggregation.
The team, co-led by Sonia Vallabh and Jonathan Weissman, made a fusion of the non-enzymatic C-terminal domain of the epigenetic regulator DNMT3L and a histone H3 tail. Together, they recruit the endogenous methyltransferase DNMT3A to silence a target gene, specified by an attached zinc-finger protein (ZFP), by methylating its promoter…
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- Source: https://www.biocentury.com/article/652857/science-spotlight-epigenetic-editor-for-brain-prion-silencing-mopac-s-oral-biologics-and-more