ARTICLE | Discovery & Translation
BioCentury’s roundup of translational innovations
By Danielle Golovin, Senior Biopharma Analyst
June 6, 2024 12:09 AM UTC
A team led by serial entrepreneur and Stanford University professor Crystal Mackall revealed a method to increase the antitumor efficacy of anti-CD47 mAbs for solid tumors.
Blocking of the CD47-SIRPA pathway, by which cancers send a ‘don’t eat me’ signal to the immune system, can lead to increased macrophage-mediated phagocytosis of tumor cells, but has led to limited efficacy in the clinic. To further increase tumor cell killing, the Nature paper authors combined an anti-CD47 mAb with tumor-targeted CAR T cells. The strategy was stymied, however, by rapid macrophage-mediated clearance of the CAR Ts…
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- Source: https://www.biocentury.com/article/652610/science-spotlight-engineered-cd47-protects-car-t-cells-from-macrophages-and-more