ARTICLE | Discovery & Translation
BioCentury’s roundup of translational innovations
By Danielle Golovin, Senior Biopharma Analyst
March 2, 2024 12:56 AM UTC


A peptide-based strategy for enhancing cellular uptake of a non-viral CRISPR system could enable in vivo use of more precise and less immunogenic genome editors.
CRISPR ribonucleoprotein (RNP) genome editors’ advantages over virally delivered CRISPR machinery include reduced off-target and immunogenic effects. The RNP carries the Cas protein and guide RNA directly, without relying on a delivery vector, but its ability to enter cells is limited. …
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- Source: https://www.biocentury.com/article/651594/science-spotlight-doudna-lab-s-cell-penetrating-crispr-rnps-durable-epigenome-editing-and-more