The cells that surround tumours can influence tumour growth and response to therapy. In new research, ChuanJie Zhang and colleagues report the identification of a subset of pericytes that sustain the proliferation of cancer stem cells (CSCs) in clear cell renal cell carcinoma (ccRCC) and promote tumour resistance to tyrosine kinase inhibitors (TKIs).
PDGFRβ+GPR91+ pericytes, identified by single-cell RNA sequencing, were significantly enriched in ccRCC tumours compared to their levels in non-malignant adjacent kidney tissue. Moreover, PDGFRβ+GPR91+ frequency was associated with poorer outcomes and reduced sensitivity to TKI therapy. These findings were confirmed in mouse models of ccRCC, demonstrating that PDGFRβ+GPR91+ pericytes support tumour growth through the maintenance of CSCs, are themselves resistant to TKIs and also render tumours resistant to TKIs.
- SEO Powered Content & PR Distribution. Get Amplified Today.
- PlatoData.Network Vertical Generative Ai. Empower Yourself. Access Here.
- PlatoAiStream. Web3 Intelligence. Knowledge Amplified. Access Here.
- PlatoESG. Carbon, CleanTech, Energy, Environment, Solar, Waste Management. Access Here.
- PlatoHealth. Biotech and Clinical Trials Intelligence. Access Here.
- Source: https://renal.platohealth.ai/pericyte-stem-cell-crosstalk-in-ccrcc-nature-reviews-nephrology/