Del Dosso, A., Urenda, J.-P., Nguyen, T. & Quadrato, G. Upgrading the physiological relevance of human brain organoids. Neuron 107, 1014–1028 (2020).
Urenda, J.-P., Dosso, A. D., Birtele, M. & Quadrato, G. Present and future modeling of human psychiatric connectopathies with brain organoids. Biol. Psychiatry 93, 606–615 (2023).
Eichmüller, O. L. & Knoblich, J. A. Human cerebral organoids—a new tool for clinical neurology research. Nat. Rev. Neurol. 18, 661–680 (2022).
Atamian, A., Cordón-Barris, L. & Quadrato, G. Taming human brain organoids one cell at a time. Semin. Cell Dev. Biol. 111, 23–31 (2021).
Wilson, S. W. & Houart, C. Early steps in the development of the forebrain. Dev. Cell 6, 167–181 (2004).
Schmahmann, J. D. The cerebellum and cognition. Neurosci. Lett. 688, 62–75 (2019).
Zhang, P. et al. The cerebellum and cognitive neural networks. Front. Hum. Neurosci. 17, 1197459 (2023).
Barton, R. A. & Venditti, C. Rapid evolution of the cerebellum in humans and other great apes. Curr. Biol. 24, 2440–2444 (2014).
Haldipur, P. et al. Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum. Science 366, 454–460 (2019).
Aldinger, K. A. et al. Spatial and cell type transcriptional landscape of human cerebellar development. Nat. Neurosci. 24, 1163–1175 (2021).
Sepp, M. et al. Cellular development and evolution of the mammalian cerebellum. Nature 625, 788–796 (2024).
Atamian, A. et al. Human cerebellar organoids with functional Purkinje cells. Cell Stem Cell 31, 39–51.e6 (2024).
Liu, A., Losos, K. & Joyner, A. L. FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate. Development 126, 4827–4838 (1999).
Martinez, S., Crossley, P. H., Cobos, I., Rubenstein, J. L. R. & Martin, G. R. FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression. Development 126, 1189–1200 (1999).
Garda, A.-L., Echevarrı́a, D. & Martı́nez, S. Neuroepithelial co-expression of Gbx2 and Otx2 precedes Fgf8 expression in the isthmic organizer. Mech. Dev. 101, 111–118 (2001).
Sundberg, M. et al. Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin. Mol. Psychiatry 23, 2167–2183 (2018).
Buchholz, D. E. et al. Novel genetic features of human and mouse Purkinje cell differentiation defined by comparative transcriptomics. Proc. Natl Acad. Sci. USA 117, 15085–15095 (2020).
Quadrato, G. & Arlotta, P. Present and future of modeling human brain development in 3D organoids. Curr. Opin. Cell Biol. 49, 47–52 (2017).
Chambers, S. M. et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 27, 275–280 (2009).
Muguruma, K., Nishiyama, A., Kawakami, H., Hashimoto, K. & Sasai, Y. Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells. Cell Rep. 10, 537–550 (2015).
Nordström, U., Jessell, T. M. & Edlund, T. Progressive induction of caudal neural character by graded Wnt signaling. Nat. Neurosci. 5, 525–532 (2002).
Hidalgo-Sánchez, M., Millet, S., Simeone, A. & Alvarado-Mallart, R.-M. Comparative analysis of Otx2, Gbx2, Pax2, Fgf8 and Wnt1 gene expressions during the formation of the chick midbrain/hindbrain domain. Mech. Dev. 81, 175–178 (1999).
Sato, T., Araki, I. & Nakamura, H. Inductive signal and tissue responsiveness defining the tectum and the cerebellum. Development 128, 2461–2469 (2001).
Hendrickx, M., Van, X. H. & Leyns, L. Anterior–posterior patterning of neural differentiated embryonic stem cells by canonical Wnts, Fgfs, Bmp4 and their respective antagonists. Dev. Growth Differ. 51, 687–698 (2009).
Jo, J. et al. Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin-producing neurons. Cell Stem Cell 19, 248–257 (2016).
Green, D., Whitener, A. E., Mohanty, S. & Lekven, A. C. Vertebrate nervous system posteriorization: grading the function of Wnt signaling. Dev. Dyn. 244, 507–512 (2015).
Nakamura, H., Katahira, T., Matsunaga, E. & Sato, T. Isthmus organizer for midbrain and hindbrain development. Brain Res. Rev. 49, 120–126 (2005).
Chi, C. L., Martinez, S., Wurst, W. & Martin, G. R. The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum. Development 130, 2633–2644 (2003).
Zou, Y.-R., Kottmann, A. H., Kuroda, M., Taniuchi, I. & Littman, D. R. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393, 595–599 (1998).
Vilz, T. O. et al. The SDF‐1/CXCR4 pathway and the development of the cerebellar system. Eur. J. Neurosci. 22, 1831–1839 (2005).
He, Z. et al. An integrated transcriptomic cell atlas of human neural organoids. Preprint at bioRxiv https://doi.org/10.1101/2023.10.05.561097 (2023).
Smith, K. S. et al. Unified rhombic lip origins of group 3 and group 4 medulloblastoma. Nature 609, 1012–1020 (2022).
Hendrikse, L. D. et al. Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature 609, 1021–1028 (2022).
Tanaka, D., Nakaya, Y., Yanagawa, Y., Obata, K. & Murakami, F. Multimodal tangential migration of neocortical GABAergic neurons independent of GPI-anchored proteins. Development 130, 5803–5813 (2003).
Ang, E. S. B. C., Haydar, T. F., Gluncic, V. & Rakic, P. Four-dimensional migratory coordinates of GABAergic interneurons in the developing mouse cortex. J. Neurosci. 23, 5805–5815 (2003).
Tanaka, D. H., Maekawa, K., Yanagawa, Y., Obata, K. & Murakami, F. Multidirectional and multizonal tangential migration of GABAergic interneurons in the developing cerebral cortex. Development 133, 2167–2176 (2006).
Martini, F. J. et al. Biased selection of leading process branches mediates chemotaxis during tangential neuronal migration. Development 136, 41–50 (2009).
Britto, J. M., Johnston, L. A. & Tan, S.-S. The stochastic search dynamics of interneuron migration. Biophys. J. 97, 699–709 (2009).
Tanaka, D. H. et al. Random walk behavior of migrating cortical interneurons in the marginal zone: time-lapse analysis in flat-mount cortex. J. Neurosci. 29, 1300–1311 (2009).
Hansen, D. V. et al. Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences. Nat. Neurosci. 16, 1576–1587 (2013).
Ma, T. et al. Subcortical origins of human and monkey neocortical interneurons. Nat. Neurosci. 16, 1588–1597 (2013).
Barlow, C. et al. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86, 159–171 (1996).
Choy, K. R. & Watters, D. J. Neurodegeneration in ataxia-telangiectasia: multiple roles of ATM kinase in cellular homeostasis: ATM and cellular homeostasis. Dev. Dyn. 247, 33–46 (2018).
Hashimoto, K. & Kano, M. Postnatal development and synapse elimination of climbing fiber to Purkinje cell projection in the cerebellum. Neurosci. Res. 53, 221–228 (2005).
Sotelo, C. Cellular and genetic regulation of the development of the cerebellar system. Prog. Neurobiol. 72, 295–339 (2004).
Sotelo, C. & Chédotal, A. Development of the olivocerebellar system: migration and formation of cerebellar maps. Prog. Brain Res. 148, 1–20 (2005).
Rahimi-Balaei, M. et al. Embryonic stages in cerebellar afferent development. Cerebellum Ataxias 2, 7 (2015).
Ito, M. Cerebellar circuitry as a neuronal machine. Prog. Neurobiol. 78, 272–303 (2006).
Ito, M. Control of mental activities by internal models in the cerebellum. Nat. Rev. Neurosci. 9, 304–313 (2008).
Madhavan, M. et al. Induction of myelinating oligodendrocytes in human cortical spheroids. Nat. Methods 15, 700–706 (2018).
Marton, R. M. et al. Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures. Nat. Neurosci. 22, 484–491 (2019).
Cakir, B. et al. Engineering of human brain organoids with a functional vascular-like system. Nat. Methods 16, 1169–1175 (2019).
Lin, Y.-T. et al. APOE4 causes widespread molecular and cellular alterations associated with Alzheimer’s disease phenotypes in human iPSC-derived brain cell types. Neuron 98, 1141–1154.e7 (2018).
Song, L. et al. Functionalization of brain region-specific spheroids with isogenic microglia-like cells. Sci. Rep. 9, 11055 (2019).
Bejoy, J. et al. Genomics analysis of metabolic pathways of human stem cell-derived microglia-like cells and the integrated cortical spheroids. Stem Cells Int. 2019, 2382534 (2019).
Popova, G. et al. Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids. Cell Stem Cell 28, 2153–2166.e6 (2021).
Velmeshev, D. et al. Single-cell analysis of prenatal and postnatal human cortical development. Science 382, eadf0834 (2023).
Bhaduri, A. et al. An atlas of cortical arealization identifies dynamic molecular signatures. Nature 598, 200–204 (2021).
Mathys, H. et al. Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology. Cell 186, 4365–4385.e27 (2023).
Polioudakis, D. et al. A single cell transcriptomic atlas of human neocortical development during mid-gestation. Neuron 103, 785–801.e8 (2019).
Langseth, C. M. et al. Comprehensive in situ mapping of human cortical transcriptomic cell types. Commun. Biol. 4, 998 (2021).
Silva, T. P. et al. Maturation of human pluripotent stem cell-derived cerebellar neurons in the absence of co-culture. Front. Bioeng. Biotechnol. 8, 70 (2020).
Nayler, S., Agarwal, D., Curion, F., Bowden, R. & Becker, E. B. E. High-resolution transcriptional landscape of xeno-free human induced pluripotent stem cell-derived cerebellar organoids. Sci. Rep. 11, 12959 (2021).
Chen, Y. et al. Generation of advanced cerebellar organoids for neurogenesis and neuronal network development. Hum. Mol. Genet. 32, 2832–2841 (2023).
Silva, T. P. et al. Transcriptome profiling of human pluripotent stem cell-derived cerebellar organoids reveals faster commitment under dynamic conditions. Biotechnol. Bioeng. 118, 2781–2803 (2021).
Watson, L. M., Wong, M. M. K., Vowles, J., Cowley, S. A. & Becker, E. B. E. A simplified method for generating purkinje cells from human-induced pluripotent stem cells. Cerebellum 17, 419–427 (2018).
Hua, T. T. et al. Cerebellar differentiation from human stem cells through retinoid, wnt, and sonic hedgehog pathways. Tissue Eng. A 27, 881–893 (2021).
Muguruma, K. et al. Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells. Nat. Neurosci. 13, 1171–1180 (2010).
Giovannucci, A. et al. CaImAn an open source tool for scalable calcium imaging data analysis. eLife 8, e38173 (2019).
Siletti, K. et al. Transcriptomic diversity of cell types across the adult human brain. Science 382, eadd7046 (2023).
Kompaníková, P. & Bryja, V. Regulation of choroid plexus development and its functions. Cell. Mol. Life Sci. 79, 304 (2022).
Gruol, D. & Franklin, C. Morphological and physiological differentiation of Purkinje neurons in cultures of rat cerebellum. J. Neurosci. 7, 1271–1293 (1987).
Raman, I. M. & Bean, B. P. Ionic currents underlying spontaneous action potentials in isolated cerebellar purkinje neurons. J. Neurosci. 19, 1663–1674 (1999).
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