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Dual T cell depletion for graft versus host disease prevention in peripheral blood haploidentical hematopoietic cell transplantation for adults with hematological malignancies – Bone Marrow Transplantation

  • Rimando J, McCurdy SR, Luznik L. How I prevent GVHD in high-risk patients: posttransplant cyclophosphamide and beyond. Blood. 2023;141:49–59.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Auletta JJ, Kou J, Chen M, Bolon YT, Broglie L, Bupp C, et al. Real-world data showing trends and outcomes by race and ethnicity in allogeneic hematopoietic cell transplantation: a report from the center for international blood and marrow transplant research. Transpl Cell Ther. 2023;29:346.e1–346.e10.

    Article 
    CAS 

    Google Scholar
     

  • Fuchs EJ, McCurdy SR, Solomon SR, Wang T, Herr MR, Modi D, et al. HLA informs risk predictions after haploidentical stem cell transplantation with posttransplantation cyclophosphamide. Blood. 2022;139:1452–68.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kasamon YL, Bolaños-Meade J, Prince GT, Tsai HL, McCurdy SR, Kanakry JA, et al. Outcomes of nonmyeloablative HLA-haploidentical blood or marrow transplantation with high-dose post-transplantation cyclophosphamide in older adults. J Clin Oncol. 2015;33:3152–61.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • McCurdy SR, Radojcic V, Tsai HL, Vulic A, Thompson E, Ivcevic S, et al. Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning. Blood. 2022;139:608–23.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Luznik L, Jalla S, Engstrom LW, Iannone R, Fuchs EJ. Durable engraftment of major histocompatibility complex–incompatible cells after nonmyeloablative conditioning with fludarabine, low-dose total body irradiation, and posttransplantation cyclophosphamide. Blood. 2001;98:3456–64.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ho VT, Soiffer RJ. The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation. Blood. 2001;98:3192–204.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bolaños-Meade J, Hamadani M, Wu J, Al Malki MM, Martens MJ, Runaas L, et al. Post-transplantation cyclophosphamide-based graft-versus-host disease prophylaxis. N Engl J Med. 2023;388:2338–48.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Suárez EU. Hottest topics in hematopoietic stem cell transplantation: a summary from the 8th International Transplant and Cellular Therapy Course. Clin Hematol Int [Internet]. Oct 18 [cited 2023 Dec 13];5. Available from: https://chi.scholasticahq.com/article/89034-hottest-topics-in-hematopoietic-stem-cell-transplantation-a-summary-from-the-8th-international-transplant-and-cellular-therapy-course (2023).

  • Gooptu M, Romee R, St. Martin A, Arora M, Al Malki M, Antin JH, et al. HLA-haploidentical vs matched unrelated donor transplants with posttransplant cyclophosphamide-based prophylaxis. Blood. 2021;138:273–82.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Barkhordar M, Kasaeian A, Janbabai G, Mousavi SA, Fumani HK, Tavakoli S, et al. Outcomes of haploidentical peripheral stem cell transplantation with combination of post-transplant cyclophosphamide (PTCy) and anti-thymocyte globulin (ATG) compared to unrelated donor transplantation in acute myeloid leukemia: A retrospective 10-year experience. Leuk Res. 2022;120:106918.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Saliba RM, Alousi AM, Pidala J, Arora M, Spellman SR, Hemmer MT, et al. Characteristics of graft-versus-host disease (GvHD) after post-transplantation cyclophosphamide versus conventional GvHD prophylaxis. Transpl Cell Ther. 2022;28:681–93.

    Article 
    CAS 

    Google Scholar
     

  • Bejanyan N, Pidala JA, Wang X, Thapa R, Nishihori T, Elmariah H, et al. A phase 2 trial of GVHD prophylaxis with PTCy, sirolimus, and MMF after peripheral blood haploidentical transplantation. Blood Adv. 2021;5:1154–63.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Auletta J, Chen M, Shaw B. Current use and outcome of hematopoietic stem cell transplantation: CIBMTR US summary slides, 2021. [Internet]. Power Point Presentation presented at; [cited 2023 Feb 28]. Available from: https://cibmtr.org/CIBMTR/Resources/Summary-Slides-Reports

  • Salas MQ, Charry P, Pedraza A, Martínez-Cibrian N, Solano MT, Domènech A, et al. PTCY and tacrolimus for GVHD prevention for older adults undergoing HLA-matched sibling and unrelated donor AlloHCT. Transpl Cell Ther. 2022;28:489.e1–489.e9.

    Article 
    CAS 

    Google Scholar
     

  • Modi D, Kondrat K, Kim S, Deol A, Ayash L, Ratanatharathorn V, et al. Post-transplant cyclophosphamide versus thymoglobulin in hla-mismatched unrelated donor transplant for acute myelogenous leukemia and myelodysplastic syndrome. Transpl Cell Ther. 2021;27:760–7.

    Article 
    CAS 

    Google Scholar
     

  • Finke J, Bethge WA, Schmoor C, Ottinger HD, Stelljes M, Zander AR, et al. Standard graft-versus-host disease prophylaxis with or without anti-T-cell globulin in haematopoietic cell transplantation from matched unrelated donors: a randomised, open-label, multicentre phase 3 trial. Lancet Oncol. 2009;10:855–64.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bacigalupo A, Lamparelli T, Bruzzi P, Guidi S, Alessandrino PE, di Bartolomeo P, et al. Antithymocyte globulin for graft-versus-host disease prophylaxis in transplants from unrelated donors: 2 randomized studies from Gruppo Italiano Trapianti Midollo Osseo (GITMO). Blood. 2001;98:2942–7.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xu X, Yang J, Cai Y, Li S, Niu J, Zhou K, et al. Low dose anti-thymocyte globulin with low dose posttransplant cyclophosphamide (low dose ATG/PTCy) can reduce the risk of graft-versus-host disease as compared with standard-dose anti-thymocyte globulin in haploidentical peripheral hematopoietic stem cell transplantation combined with unrelated cord blood. Bone Marrow Transpl. 2021;56:705–8.

    Article 
    CAS 

    Google Scholar
     

  • Anasetti C, Logan BR, Lee SJ, Waller EK, Weisdorf DJ, Wingard JR, et al. Peripheral-Blood Stem Cells versus Bone Marrow from Unrelated Donors. N. Engl J Med. 2012;367:1487–96.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Carreras E, Dufour C, Mohty M, Kröger N, editors. The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies [Internet]. Cham: Springer International Publishing [cited 2023 Mar 24]. Available from: http://link.springer.com/10.1007/978-3-030-02278-5; (2019)

  • Martino R, Romero P, Subirá M, Bellido M, Altés A, Sureda A, et al. Comparison of the classic Glucksberg criteria and the IBMTR Severity Index for grading acute graft-versus-host disease following HLA-identical sibling stem cell transplantation. Bone Marrow Transpl. 1999;24:283–7.

    Article 
    CAS 

    Google Scholar
     

  • Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, et al. National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 Diagnosis and Staging Working Group Report. Biol Blood Marrow Transpl. 2015;21:389–401.e1.

    Article 

    Google Scholar
     

  • Alfaro Moya T, Mattsson J, Remberger M, Lipton JH, Kim DD, Viswabandya A, et al. Influence of conditioning regimen intensity on outcomes post‐allogeneic hematopoietic cell transplantation for acute myeloid leukemia in complete morphological remission. Eur J Haematol. 2023;111:553–61.

    Article 
    PubMed 

    Google Scholar
     

  • Bashey A, Zhang MJ, McCurdy SR, St. Martin A, Argall T, Anasetti C, et al. Mobilized peripheral blood stem cells versus unstimulated bone marrow as a graft source for T-cell–replete haploidentical donor transplantation using post-transplant cyclophosphamide. J Clin Oncol. 2017;35:3002–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Battipaglia G, Labopin M, Blaise D, Diez-Martin JL, Bazarbachi A, Vitek A, et al. Impact of the addition of antithymocyte globulin to post-transplantation cyclophosphamide in haploidentical transplantation with peripheral blood compared to post-transplantation cyclophosphamide alone in acute myelogenous leukemia: a retrospective study on behalf of the acute leukemia working party of the European Society for Blood and Marrow Transplantation. Transpl Cell Ther. 2022;28:587.e1–587.e7.

    Article 
    CAS 

    Google Scholar
     

  • Salas MQ, Atenafu EG, Law AD, Lam W, Pasic I, Chen C, et al. Experience using anti-thymocyte globulin with post-transplantation cyclophosphamide for graft-versus-host disease prophylaxis in peripheral blood haploidentical stem cell transplantation. Transpl Cell Ther. 2021;27:428.e1–428.e9.

    Article 
    CAS 

    Google Scholar
     

  • Moore J, Hamad N, Gottlieb D, Bajel A, Ritchie D, Yeung D, et al. Early cessation of calcineurin inhibitors is feasible post–haploidentical blood stem cell transplant: the ANZHIT 1 study. Blood Adv. 2023;7:5554–65.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Duléry R, Bastos J, Paviglianiti A, Malard F, Brissot E, Battipaglia G, et al. Thiotepa, busulfan, and fludarabine conditioning regimen in T cell-replete HLA-haploidentical hematopoietic stem cell transplantation. Biol Blood Marrow Transpl. 2019;25:1407–15.

    Article 

    Google Scholar
     

  • El-Cheikh J, Devillier R, Dulery R, Massoud R, Al Chami F, Ghaoui N, et al. Impact of adding antithymocyte globulin to posttransplantation cyclophosphamide in haploidentical stem-cell transplantation. Clin Lymphoma Myeloma Leuk. 2020;20:617–23.

    Article 
    PubMed 

    Google Scholar
     

  • Sun YQ, Wang Y, Wang FR, Yan CH, Cheng YF, Chen YH, et al. Graft failure in patients with hematological malignancies: a successful salvage with a second transplantation from a different haploidentical donor. Front Med. 2021;8:604085.

    Article 

    Google Scholar
     

  • Giménez E, Torres I, Albert E, Piñana JL, Hernández-Boluda JC, Solano C, et al. Cytomegalovirus (CMV) infection and risk of mortality in allogeneic hematopoietic stem cell transplantation (Allo-HSCT): A systematic review, meta-analysis, and meta-regression analysis. Am J Transpl. 2019;19:2479–94.

    Article 

    Google Scholar
     

  • Styczynski J, Gil L, Tridello G, Ljungman P, Donnelly JP, Van Der Velden W, et al. Response to rituximab-based therapy and risk factor analysis in Epstein Barr virus–related lymphoproliferative disorder after hematopoietic stem cell transplant in children and adults: a study from the infectious diseases Working Party of the European Group for Blood and Marrow Transplantation. Clin Infect Dis. 2013;57:794–802.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Styczynski J, Reusser P, Einsele H, De La Camara R, Cordonnier C, Ward KN, et al. Management of HSV, VZV and EBV infections in patients with hematological malignancies and after SCT: guidelines from the Second European Conference on Infections in Leukemia. Bone Marrow Transpl. 2009;43:757–70.

    Article 
    CAS 

    Google Scholar
     

  • Carreira AS, Salas MQ, Remberger M, Basso IN, Law AD, Lam W, et al. Bloodstream Infections and Outcomes Following Allogeneic Hematopoietic Cell Transplantation: A Single-Center Study. Transpl Cell Ther. 2022;28:50.e1–50.e8.

    Article 
    CAS 

    Google Scholar
     

  • Duléry R, Malard F, Brissot E, Banet A, Sestili S, Belhocine R, et al. Reduced post-transplant cyclophosphamide dose with antithymocyte globulin in peripheral blood stem cell haploidentical transplantation. Bone Marrow Transplant [Internet]. Aug 18 [cited 2023 Oct 13]; Available from: https://www.nature.com/articles/s41409-023-02085-2 (2023).

  • Raiola AM, Angelucci E, Sica S, Bacigalupo A. Haploidentical bone marrow transplants with post transplant cyclophosphamide on day + 3 + 5: The Genova protocol. Blood Rev. 2023;62:101031.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

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