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Distillery spotlight: new mitochondrial mechanisms from academia

ARTICLE | Discovery & Translation

Correcting mitochondrial dynamics, metabolic control of pathogenic or therapeutic cells emerge among translational innovations in BioCentury’s survey of 2023 publications

By Karen Tkach Tuzman, Director of Biopharma Intelligence

March 12, 2024 1:17 AM UTC

Insights into how mitochondria are formed, fused, divided or destroyed could guide the next generation of therapeutics that tune mitochondrial activity in disease-relevant cells. 

Mitochondrial biology is increasingly becoming a focus for newco formation and drug discovery. BioCentury’s analysis of companies that raised series A rounds in 2023 identified induction of mitophagy — the degradation of old or dysfunctional mitochondria, which triggers biogenesis of new, healthy organelles — as an emergent technology cluster.