ARTICLE | BioCentury Commentary
BioCentury’s roundup of translational innovations
By Danielle Golovin, Senior Biopharma Analyst
March 30, 2024 12:46 AM UTC
A group led by serial entrepreneur Irving Weissman made the immune system of aged mice look and function more like that of young mice by depleting a specific pool of hematopoietic stem cells (HSCs).
There are at least two previously established pools of HSCs, one that provides a balanced production of lymphoid and myeloid cells (bal-HSCs), and another that predominantly produces myeloid cells (my-HSCs). The ratio of the pools changes with age. Specifically, the pool shifts towards the my-HSCs, which results in decreased lymphopoiesis, increased myelopoiesis and reduced adaptive immunity…
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- Source: https://www.biocentury.com/article/651933/depleting-an-hsc-pool-improves-immune-function-plus-new-ms-immune-signatures-and-more