Schneider, M. R., Schmidt-Ullrich, R. & Paus, R. The hair follicle as a dynamic miniorgan. Curr. Biol. 19, R132–R142 (2009).
Hsu, Y. C., Li, L. & Fuchs, E. Transit-amplifying cells orchestrate stem cell activity and tissue regeneration. Cell 157, 935–949 (2014).
Greco, V. et al. A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell 4, 155–169 (2009).
Ito, M. et al. Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat. Med. 11, 1351–1354 (2005).
Lee, S. A., Li, K. N. & Tumbar, T. Stem cell-intrinsic mechanisms regulating adult hair follicle homeostasis. Exp. Dermatol. 30, 430–447 (2021).
Plikus, M. V. et al. Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature 451, 340–344 (2008).
Lay, K., Kume, T. & Fuchs, E. FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential. Proc. Natl Acad. Sci. USA 113, E1506–E1515 (2016).
Wang, L., Siegenthaler, J. A., Dowell, R. D. & Yi, R. Foxc1 reinforces quiescence in self-renewing hair follicle stem cells. Science 351, 613–617 (2016).
Horsley, V., Aliprantis, A. O., Polak, L., Glimcher, L. H. & Fuchs, E. NFATc1 balances quiescence and proliferation of skin stem cells. Cell 132, 299–310 (2008).
Choi, Y. S. et al. Distinct functions for Wnt/beta-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell 13, 720–733 (2013).
Sennett, R. & Rendl, M. Mesenchymal-epithelial interactions during hair follicle morphogenesis and cycling. Semin. Cell Dev. Biol. 23, 917–927 (2012).
Chen, C. L., Huang, W. Y., Wang, E. H. C., Tai, K. Y. & Lin, S. J. Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration. J. Biomed. Sci. 27, 43 (2020).
Jang, H., Jo, Y., Lee, J. H. & Choi, S. Aging of hair follicle stem cells and their niches. BMB Rep. 56, 2–9 (2023).
Paus, R., Nickoloff, B. J. & Ito, T. A. ‘hairy’ privilege. Trends Immunol. 26, 32–40 (2005).
Bertolini, M., McElwee, K., Gilhar, A., Bulfone-Paus, S. & Paus, R. Hair follicle immune privilege and its collapse in alopecia areata. Exp. Dermatol 29, 703–725 (2020).
Pratt, C. H., King, L. E. Jr., Messenger, A. G., Christiano, A. M. & Sundberg, J. P. Alopecia areata. Nat. Rev. Dis. Prim. 3, 17011 (2017).
Inui, S. & Itami, S. Androgen actions on the human hair follicle: perspectives. Exp. Dermatol 22, 168–171 (2013).
Ohnemus, U. et al. Hair cycle control by estrogens: catagen induction via estrogen receptor (ER)-alpha is checked by ER beta signaling. Endocrinology 146, 1214–1225 (2005).
Craven, A. J. et al. Prolactin signaling influences the timing mechanism of the hair follicle: analysis of hair growth cycles in prolactin receptor knockout mice. Endocrinology 142, 2533–2539 (2001).
Redler, S., Messenger, A. G. & Betz, R. C. Genetics and other factors in the aetiology of female pattern hair loss. Exp. Dermatol 26, 510–517 (2017).
Lutz, G. Hair loss and hyperprolactinemia in women. Dermatoendocrinol 4, 65–71 (2012).
Paus, R., Bulfone-Paus, S. & Bertolini, M. Hair follicle immune privilege revisited: the key to alopecia areata management. J. Investig. Dermatol Symp. Proc. 19, S12–S17 (2018).
Anzai, A., Wang, E. H. C., Lee, E. Y., Aoki, V. & Christiano, A. M. Pathomechanisms of immune-mediated alopecia. Int Immunol. 31, 439–447 (2019).
Randall, V. A. Hormonal regulation of hair follicles exhibits a biological paradox. Semin. Cell Dev. Biol. 18, 274–285 (2007).
Costin, G. E. & Hearing, V. J. Human skin pigmentation: melanocytes modulate skin color in response to stress. FASEB J. 21, 976–994 (2007).
Lin, J. Y. & Fisher, D. E. Melanocyte biology and skin pigmentation. Nature 445, 843–850 (2007).
Dreno, B. et al. Microbiome in healthy skin, update for dermatologists. J. Eur. Acad. Dermatol Venereol. 30, 2038–2047 (2016).
Geueke, A. & Niemann, C. Stem and progenitor cells in sebaceous gland development, homeostasis and pathologies. Exp. Dermatol 30, 588–597 (2021).
Torkamani, N., Rufaut, N. W., Jones, L. & Sinclair, R. Destruction of the arrector pili muscle and fat infiltration in androgenic alopecia. Br. J. Dermatol 170, 1291–1298 (2014).
Muller-Rover, S. et al. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J. Invest Dermatol 117, 3–15 (2001).
Augustyniak, A. & Mc Mahon, H. Dietary marine-derived ingredients for stimulating hair cell cycle. Biomed. Pharmacother. 163, 114838 (2023).
Rezza, A., Sennett, R. & Rendl, M. Adult stem cell niches: cellular and molecular components. Curr. Top. Dev. Biol. 107, 333–372 (2014).
Yi, R. Concise review: mechanisms of quiescent hair follicle stem cell regulation. Stem Cells 35, 2323–2330 (2017).
Hsu, Y. C., Pasolli, H. A. & Fuchs, E. Dynamics between stem cells, niche, and progeny in the hair follicle. Cell 144, 92–105 (2011).
Hagner, A. et al. Transcriptional profiling of the adult hair follicle mesenchyme reveals r-spondin as a novel regulator of dermal progenitor function. iScience 23, 101019 (2020).
Fuchs, E. & Blau, H. M. Tissue stem cells: architects of their niches. Cell Stem Cell 27, 532–556 (2020).
Yang, H., Adam, R. C., Ge, Y., Hua, Z. L. & Fuchs, E. Epithelial-mesenchymal micro-niches govern stem cell lineage choices. Cell 169, 483–496.e413 (2017).
Rompolas, P., Mesa, K. R. & Greco, V. Spatial organization within a niche as a determinant of stem-cell fate. Nature 502, 513–518 (2013).
Heitman, N. et al. Dermal sheath contraction powers stem cell niche relocation during hair cycle regression. Science 367, 161–166 (2020).
Nishimura, E. K. et al. Dominant role of the niche in melanocyte stem-cell fate determination. Nature 416, 854–860 (2002).
Nishimura, E. K. Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation. Pigment Cell Melanoma Res. 24, 401–410 (2011).
Qiu, W., Chuong, C. M. & Lei, M. Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials. Exp. Dermatol 28, 395–405 (2019).
Chou, W. C. et al. Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling. Nat. Med. 19, 924–929 (2013).
Niemann, C. & Horsley, V. Development and homeostasis of the sebaceous gland. Semin. Cell Dev. Biol. 23, 928–936 (2012).
Frances, D. & Niemann, C. Stem cell dynamics in sebaceous gland morphogenesis in mouse skin. Dev. Biol. 363, 138–146 (2012).
Fischer, H. et al. Holocrine secretion of sebum is a unique dnase2-dependent mode of programmed cell death. J. Invest. Dermatol. 137, 587–594 (2017).
Schneider, M. R. & Paus, R. Sebocytes, multifaceted epithelial cells: lipid production and holocrine secretion. Int. J. Biochem. Cell Biol. 42, 181–185 (2010).
Zouboulis, C. C. et al. Beyond acne: current aspects of sebaceous gland biology and function. Rev. Endocr. Metab. Disord. 17, 319–334 (2016).
Moore, K. A. & Lemischka, I. R. Stem cells and their niches. Science 311, 1880–1885 (2006).
Li, K. N. & Tumbar, T. Hair follicle stem cells as a skin-organizing signaling center during adult homeostasis. EMBO J. 40, e107135 (2021).
Hsu, Y. C., Li, L. & Fuchs, E. Emerging interactions between skin stem cells and their niches. Nat. Med. 20, 847–856 (2014).
Brunet, A., Goodell, M. A. & Rando, T. A. Ageing and rejuvenation of tissue stem cells and their niches. Nat. Rev. Mol. Cell Biol. 24, 45–62 (2023).
Hsu, Y. C. & Fuchs, E. Building and maintaining the skin. Cold Spring Harb. Perspect. Biol. 14, a040840 (2022).
Castellana, D., Paus, R. & Perez-Moreno, M. Macrophages contribute to the cyclic activation of adult hair follicle stem cells. PLoS Biol. 12, e1002002 (2014).
Gur-Cohen, S. et al. Stem cell-driven lymphatic remodeling coordinates tissue regeneration. Science 366, 1218–1225 (2019).
Genander, M. et al. BMP signaling and its pSMAD1/5 target genes differentially regulate hair follicle stem cell lineages. Cell Stem Cell 15, 619–633 (2014).
Kobielak, K., Stokes, N., de la Cruz, J., Polak, L. & Fuchs, E. Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Proc. Natl Acad. Sci. USA 104, 10063–10068 (2007).
Kimura-Ueki, M. et al. Hair cycle resting phase is regulated by cyclic epithelial FGF18 signaling. J. Invest. Dermatol. 132, 1338–1345 (2012).
Gay, D. et al. Fgf9 from dermal gammadelta T cells induces hair follicle neogenesis after wounding. Nat. Med. 19, 916–923 (2013).
Harel, S. et al. Pharmacologic inhibition of JAK-STAT signaling promotes hair growth. Sci. Adv. 1, e1500973 (2015).
Wang, E. C. E., Dai, Z., Ferrante, A. W., Drake, C. G. & Christiano, A. M. A subset of TREM2(+) dermal macrophages secretes oncostatin M to maintain hair follicle stem cell quiescence and inhibit hair growth. Cell Stem Cell 24, 654–669 e656 (2019).
Myung, P. S., Takeo, M., Ito, M. & Atit, R. P. Epithelial Wnt ligand secretion is required for adult hair follicle growth and regeneration. J. Invest. Dermatol. 133, 31–41 (2013).
Leiros, G. J., Ceruti, J. M., Castellanos, M. L., Kusinsky, A. G. & Balana, M. E. Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia. Mol. Cell. Endocrinol. 439, 26–34 (2017).
Lien, W. H. et al. In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators. Nat. Cell Biol. 16, 179–190 (2014).
Folgueras, A. R. et al. Architectural niche organization by LHX2 is linked to hair follicle stem cell function. Cell Stem Cell 13, 314–327 (2013).
Leishman, E. et al. Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18. Development 140, 3809–3818 (2013).
Osorio, K. M. et al. Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation. Development 135, 1059–1068 (2008).
Chen, J. K. et al. IRX5 promotes DNA damage repair and activation of hair follicle stem cells. Stem Cell Rep. 18, 1227–1243 (2023).
Haensel, D. et al. An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation. EMBO Rep. 20, e46273 (2019).
Shirokova, V. et al. Foxi3 deficiency compromises hair follicle stem cell specification and activation. Stem Cells 34, 1896–1908 (2016).
Adam, R. C. et al. Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice. Nature 521, 366–370 (2015).
Ren, X. et al. Lgr4 deletion delays the hair cycle and inhibits the activation of hair follicle stem cells. J. Invest. Dermatol. 140, 1706–1712 e1704 (2020).
Jaks, V. et al. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat. Genet. 40, 1291–1299 (2008).
Merrill, B. J., Gat, U., DasGupta, R. & Fuchs, E. Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev. 15, 1688–1705 (2001).
Wang, A. B., Zhang, Y. V. & Tumbar, T. Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation. EMBO J. 36, 61–78 (2017).
Adam, R. C. et al. NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices. Nat. Cell Biol. 22, 640–650 (2020).
Pivetti, S. et al. Loss of PRC1 activity in different stem cell compartments activates a common transcriptional program with cell type-dependent outcomes. Sci. Adv. 5, eaav1594 (2019).
Li, J. et al. Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1. J. Invest. Dermatol. 132, 2681–2690 (2012).
Rabbani, P. et al. Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration. Cell 145, 941–955 (2011).
Nishimura, E. K. et al. Key roles for transforming growth factor beta in melanocyte stem cell maintenance. Cell Stem Cell 6, 130–140 (2010).
Chang, C. Y. et al. NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche. Nature 495, 98–102 (2013).
Takeo, M. et al. EdnrB governs regenerative response of melanocyte stem cells by crosstalk with Wnt signaling. Cell Rep. 15, 1291–1302 (2016).
Botchkareva, N. V., Khlgatian, M., Longley, B. J., Botchkarev, V. A. & Gilchrest, B. A. SCF/c-kit signaling is required for cyclic regeneration of the hair pigmentation unit. FASEB J. 15, 645–658 (2001).
Liao, C. P., Booker, R. C., Morrison, S. J. & Le, L. Q. Identification of hair shaft progenitors that create a niche for hair pigmentation. Genes Dev. 31, 744–756 (2017).
Veniaminova, N. A. et al. Niche-specific factors dynamically regulate sebaceous gland stem cells in the skin. Dev. Cell 51, 326–340 e324 (2019).
Grose, R. et al. The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. EMBO J. 26, 1268–1278 (2007).
Clayton, R. W. et al. Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis. Br. J. Dermatol. 181, 677–690 (2019).
Choa, R. et al. Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion. Science 373, eabd2893 (2021).
Kobayashi, T. et al. Homeostatic control of sebaceous glands by innate lymphoid cells regulates commensal bacteria equilibrium. Cell 176, 982–997.e916 (2019).
Paus, R., Ito, N., Takigawa, M. & Ito, T. The hair follicle and immune privilege. J. Investig. Dermatol Symp. Proc. 8, 188–194 (2003).
Rajabi, F., Drake, L. A., Senna, M. M. & Rezaei, N. Alopecia areata: a review of disease pathogenesis. Br. J. Dermatol. 179, 1033–1048 (2018).
Paus, R., Eichmuller, S., Hofmann, U., Czarnetzki, B. M. & Robinson, P. Expression of classical and non-classical MHC class I antigens in murine hair follicles. Br. J. Dermatol. 131, 177–183 (1994).
Ito, T. et al. Collapse and restoration of MHC class-I-dependent immune privilege: exploiting the human hair follicle as a model. Am. J. Pathol. 164, 623–634 (2004).
Hamed, F. N. et al. Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRbeta-chain, which highlights the immunopathological aspect of the disease. PLoS ONE 14, e0210308 (2019).
Raffin, C., Vo, L. T. & Bluestone, J. A. T(reg) cell-based therapies: challenges and perspectives. Nat. Rev. Immunol. 20, 158–172 (2020).
Harries, M. J. et al. Lichen planopilaris is characterized by immune privilege collapse of the hair follicle’s epithelial stem cell niche. J. Pathol. 231, 236–247 (2013).
Meyer, K. C. et al. Evidence that the bulge region is a site of relative immune privilege in human hair follicles. Br. J. Dermatol. 159, 1077–1085 (2008).
Rosenblum, M. D., Yancey, K. B., Olasz, E. B. & Truitt, R. L. CD200, a “no danger” signal for hair follicles. J. Dermatol. Sci. 41, 165–174 (2006).
Harrist, T. J., Ruiter, D. J., Mihm, M. C. Jr. & Bhan, A. K. Distribution of major histocompatibility antigens in normal skin. Br. J. Dermatol. 109, 623–633 (1983).
Yoshida, R., Tanaka, K., Amagai, M. & Ohyama, M. Involvement of the bulge region with decreased expression of hair follicle stem cell markers in senile female cases of alopecia areata. J. Eur. Acad. Dermatol. Venereol. 25, 1346–1350 (2011).
Ito, T. et al. Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack. J. Invest. Dermatol 128, 1196–1206 (2008).
Kono, M., Nagata, H., Umemura, S., Kawana, S. & Osamura, R. Y. In situ expression of corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) genes in human skin. FASEB J. 15, 2297–2299 (2001).
Ito, N. et al. Corticotropin-releasing hormone stimulates the in situ generation of mast cells from precursors in the human hair follicle mesenchyme. J. Invest. Dermatol. 130, 995–1004 (2010).
Agudo, J. et al. Quiescent tissue stem cells evade immune surveillance. Immunity 48, 271–285 e275 (2018).
Harries, M. J. et al. Lichen planopilaris and frontal fibrosing alopecia as model epithelial stem cell diseases. Trends Mol. Med. 24, 435–448 (2018).
Ho, B. S. et al. Progressive expression of PPARGC1alpha is associated with hair miniaturization in androgenetic alopecia. Sci. Rep. 9, 8771 (2019).
Matsumura, H. et al. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. Science 351, aad4395 (2016).
Zhang, C. et al. Escape of hair follicle stem cells causes stem cell exhaustion during aging. Nat. Aging 1, 889–903 (2021).
Rathnayake, D. & Sinclair, R. Male androgenetic alopecia. Expert Opin. Pharmacother. 11, 1295–1304 (2010).
Chen, C. C. et al. Regenerative hair waves in aging mice and extra-follicular modulators follistatin, dkk1, and sfrp4. J. Invest. Dermatol. 134, 2086–2096 (2014).
Keyes, B. E. et al. Nfatc1 orchestrates aging in hair follicle stem cells. Proc. Natl Acad. Sci. USA 110, E4950–E4959 (2013).
Choi, S. et al. Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence. Nature 592, 428–432 (2021).
Ge, Y. et al. The aging skin microenvironment dictates stem cell behavior. Proc. Natl Acad. Sci. USA 117, 5339–5350 (2020).
Koester, J. et al. Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility. Nat. Cell Biol. 23, 771–781 (2021).
Salzer, M. C. et al. Identity noise and adipogenic traits characterize dermal fibroblast aging. Cell 175, 1575–1590 e1522 (2018).
Morinaga, H. et al. Obesity accelerates hair thinning by stem cell-centric converging mechanisms. Nature 595, 266–271 (2021).
Flores, A. et al. Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat. Cell Biol. 19, 1017–1026 (2017).
Reichenbach, B. et al. Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth. EMBO J. 37, e98280 (2018).
Peters, F. et al. Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling. J. Invest. Dermatol. 135, 1501–1509 (2015).
Kim, C. S. et al. Glutamine metabolism controls stem cell fate reversibility and long-term maintenance in the hair follicle. Cell Metab. 32, 629–642 e628 (2020).
Nishimura, E. K., Granter, S. R. & Fisher, D. E. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science 307, 720–724 (2005).
Inomata, K. et al. Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation. Cell 137, 1088–1099 (2009).
Dai, D. M. et al. Modeling human gray hair by irradiation as a valuable tool to study aspects of tissue aging. Geroscience 45, 1215–1230 (2023).
Zhang, B. et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature 577, 676–681 (2020).
Zarei, M., Wikramanayake, T. C., Falto-Aizpurua, L., Schachner, L. A. & Jimenez, J. J. Low level laser therapy and hair regrowth: an evidence-based review. Lasers Med. Sci. 31, 363–371 (2016).
Fertig, R. M., Gamret, A. C., Cervantes, J. & Tosti, A. Microneedling for the treatment of hair loss? J. Eur. Acad. Dermatol. Venereol. 32, 564–569 (2018).
Avci, P., Gupta, G. K., Clark, J., Wikonkal, N. & Hamblin, M. R. Low-level laser (light) therapy (LLLT) for treatment of hair loss. Lasers Surg. Med. 46, 144–151 (2014).
Varothai, S. & Bergfeld, W. F. Androgenetic alopecia: an evidence-based treatment update. Am. J. Clin. Dermatol. 15, 217–230 (2014).
Ellis, J. A. & Sinclair, R. D. Male pattern baldness: current treatments, future prospects. Drug Discov. Today 13, 791–797 (2008).
Xing, L. et al. Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition. Nat. Med. 20, 1043–1049 (2014).
Damsky, W. & King, B. A. JAK inhibitors in dermatology: the promise of a new drug class. J. Am. Acad. Dermatol. 76, 736–744 (2017).
King, B. et al. Two phase 3 trials of baricitinib for alopecia areata. N. Engl. J. Med. 386, 1687–1699 (2022).
Goldstein, J. et al. Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation. Genes Dev. 28, 983–994 (2014).
Lee, J. et al. Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo. Proc. Natl Acad. Sci. USA 110, 4634–4639 (2013).
Kadaja, M. et al. SOX9: a stem cell transcriptional regulator of secreted niche signaling factors. Genes Dev. 28, 328–341 (2014).
Hoeck, J. D. et al. Stem cell plasticity enables hair regeneration following Lgr5(+) cell loss. Nat. Cell Biol. 19, 666–676 (2017).
Adam, R. C. et al. Temporal layering of signaling effectors drives chromatin remodeling during hair follicle stem cell lineage progression. Cell Stem Cell 22, 398–413 e397 (2018).
Suen, W. J., Li, S. T. & Yang, L. T. Hes1 regulates anagen initiation and hair follicle regeneration through modulation of hedgehog signaling. Stem Cells 38, 301–314 (2020).
Li, G. et al. SIRT7 activates quiescent hair follicle stem cells to ensure hair growth in mice. EMBO J. 39, e104365 (2020).
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