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Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging

Studies

Study First Submitted Date 2022-07-11
Study First Posted Date 2022-07-14
Last Update Posted Date 2023-04-12
Start Month Year May 2024
Primary Completion Month Year February 27, 2027
Verification Month Year April 2023
Verification Date 2023-04-30
Last Update Posted Date 2023-04-12

Detailed Descriptions

Sequence: 20688383
Description This study will apply rtfMRI neurofeedback training as an intervention method, to demonstrate that healthy older adults can be trained in volitional up-regulation of ACC activity, reducing their trust-learning deficits. The study will compromise 4 MRI sessions: 1 pre-training scan, 2 training scans, and 1 post-training scan. Number and duration of scans are based on our feasibility data showing that older adults were able to up-regulate ROI activity after two 1-h training sessions. After the post-training scan, the effects of neurofeedback training on far transfer to phishing susceptibility and exploitation risks will be assessed using PEST and our survey measures.

Conditions

Sequence: 52082485 Sequence: 52082486 Sequence: 52082487
Name Neurocognitive Disorders Name Aging Name Cognitive Change
Downcase Name neurocognitive disorders Downcase Name aging Downcase Name cognitive change

Id Information

Sequence: 40087985 Sequence: 40087986
Id Source org_study_id Id Source secondary_id
Id Value IRB202200932 Id Value R01AG072658
Id Type U.S. NIH Grant/Contract
Id Link https://reporter.nih.gov/quickSearch/R01AG072658

Design Groups

Sequence: 55496379 Sequence: 55496380
Group Type Experimental Group Type Sham Comparator
Title rtfMRI-guided Neurofeedback Training Title Sham control
Description Real-time functional magnetic resonance imaging guided neurofeedback Description non-contingent-sham neurofeedback

Interventions

Sequence: 52395644 Sequence: 52395645
Intervention Type Behavioral Intervention Type Behavioral
Name rtfMRI-guided Neurofeedback Training Name Sham Control
Description Real-time functional magnetic resonance imaging guided neurofeedback is a non-invasive procedure that provides a visual of participants' current blood oxygen-level-dependent (BOLD) signal in response to a specific task or stimulus in a targeted brain region relative to a control region. Participants use real-time neurofeedback to modulate targeted BOLD signals in their own brain. This technique is used in Study 3. The study does not assess change in a health condition. It evaluates the effect of real-time functional magnetic resonance imaging guided neurofeedback (vs. sham neurofeedback) on trust-related learning in older adults. Description Sham control is the neurofeedback that was previously recorded from a patient, a non-invasive procedure used as a placebo

Keywords

Sequence: 79722421 Sequence: 79722422
Name Decision Making Name Trust
Downcase Name decision making Downcase Name trust

Design Outcomes

Sequence: 177076764
Outcome Type primary
Measure Functional Magnetic Resonance Imaging
Time Frame 90 minutes
Description Measures of neural activity are obtained using functional magnetic resonance imaging during administration of computerized learning tasks, with contrasting groups and conditions

Browse Conditions

Sequence: 193134201 Sequence: 193134202
Mesh Term Neurocognitive Disorders Mesh Term Mental Disorders
Downcase Mesh Term neurocognitive disorders Downcase Mesh Term mental disorders
Mesh Type mesh-list Mesh Type mesh-ancestor

Sponsors

Sequence: 48237182 Sequence: 48237183
Agency Class OTHER Agency Class NIH
Lead Or Collaborator lead Lead Or Collaborator collaborator
Name University of Florida Name National Institute on Aging (NIA)

Overall Officials

Sequence: 29233576
Role Principal Investigator
Name Natalie Ebner, PhD
Affiliation University of Florida

Central Contacts

Sequence: 11990297
Contact Type primary
Name Dalia El-Shafie
Phone (941)960-0427
Email elshafie.d@ufl.edu
Role Contact

Design Group Interventions

Sequence: 68031446 Sequence: 68031447
Design Group Id 55496379 Design Group Id 55496380
Intervention Id 52395644 Intervention Id 52395645

Eligibilities

Sequence: 30713899
Gender All
Minimum Age 60 Years
Maximum Age 85 Years
Healthy Volunteers No
Criteria Inclusion Criteria: Able to provide verbal and written informed consent Fluent English speaker At least 8th grade education Age between 60-85 years On stable medication regimen Exclusion Criteria: Pregnancy Magnetic resonance imaging contraindications (e.g., certain metallic objects in body, claustrophobia) Current major depression defined as scores >14 on the Beck Depression Inventory-II Impaired scores on the Telephone Interview for Cognitive Status (TICS; cut-off of >30) Current use of medications with significant anticholinergic properties due to potential influence on memory ("memory enhancing"; e.g., Aricept or Namenda) Current use of anticonvulsant, neuroleptic, sedatives, or other medications known to affect cognition Uncorrected visual and hearing impairments Neurologic conditions affecting the brain (e.g., stroke, epilepsy, traumatic brain injury with >30-minute loss of consciousness) Impaired scores on a cognitive screening measure, the Montreal Cognitive Assessment (MoCA); for older adults the cutoff will be age and education corrected Unstable medical illness (e.g., metastatic cancer) Significant cardiovascular conditions (e.g., major heart attack) Will not exclude participants who are taking anti-depressant medications. Use of antidepressants (particularly SSRI's) and anxiolytic medications will be recorded and included in post-hoc analyses
Adult True
Child False
Older Adult True

Calculated Values

Sequence: 253945297
Registered In Calendar Year 2022
Were Results Reported False
Has Single Facility False
Minimum Age Num 60
Maximum Age Num 85
Minimum Age Unit Years
Maximum Age Unit Years
Number Of Primary Outcomes To Measure 1

Designs

Sequence: 30460468
Allocation Randomized
Intervention Model Parallel Assignment
Observational Model
Primary Purpose Basic Science
Time Perspective
Masking None (Open Label)

Responsible Parties

Sequence: 28826927
Responsible Party Type Sponsor