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Evaluation of Root Resorption Following Different Mandibular Incisors Intrusive Mechanics

Studies

Study First Submitted Date 2022-05-29
Study First Posted Date 2022-06-10
Last Update Posted Date 2023-05-30
Start Month Year March 15, 2024
Primary Completion Month Year November 2024
Verification Month Year May 2023
Verification Date 2023-05-31
Last Update Posted Date 2023-05-30

Facilities

Sequence: 199855843
Name Al Azhar University
City Cairo
Country Egypt

Conditions

Sequence: 52119323 Sequence: 52119324 Sequence: 52119325
Name Orthodontic Tooth Movement Name Intrusion of Tooth Name Resorption, Root
Downcase Name orthodontic tooth movement Downcase Name intrusion of tooth Downcase Name resorption, root

Id Information

Sequence: 40118798
Id Source org_study_id
Id Value 799/2234

Countries

Sequence: 42522745
Name Egypt
Removed False

Design Groups

Sequence: 55537581 Sequence: 55537582 Sequence: 55537583
Group Type Active Comparator Group Type Active Comparator Group Type Active Comparator
Title Mini-screw Title Utility arch Title Nitinol reverse curve wire
Description 7 patients will receive an intrusive force delivered by elastics from 2 mini-screws between mandibular lateral incisor and mandibular canine. Description 7 patients will receive an intrusive force delivered by intrusive utility arch. Description 7 patients will receive an intrusive force delivered by Nitinol reverse curve wire.

Interventions

Sequence: 52434413 Sequence: 52434414 Sequence: 52434415
Intervention Type Other Intervention Type Other Intervention Type Other
Name Mini-screw Name Utility arch Name Nitinol reverse curve wire
Description 7 patients will receive an intrusive force delivered by elastics from 2 mini-screws between mandibular lateral incisor and mandibular canine. Description 7 patients will receive an intrusive force delivered by intrusive utility arch. Description 7 patients will receive an intrusive force delivered by Nitinol reverse curve wire

Keywords

Sequence: 79788661 Sequence: 79788662 Sequence: 79788663 Sequence: 79788664 Sequence: 79788665 Sequence: 79788666 Sequence: 79788667
Name Intrusion Name Root resorption Name Cone beam computed tomography Name Utility Arch Name Nitinol reverse curve wire Name Miniscrew Name Mandibular incisors
Downcase Name intrusion Downcase Name root resorption Downcase Name cone beam computed tomography Downcase Name utility arch Downcase Name nitinol reverse curve wire Downcase Name miniscrew Downcase Name mandibular incisors

Design Outcomes

Sequence: 177197160 Sequence: 177197161
Outcome Type primary Outcome Type primary
Measure Linear amount of root resorption Measure Volumetric amount of root resorption
Time Frame Change in Linear Root resorption at 6 months Time Frame Change in Volumetric Root resorption at 6 months
Description Cone beam computed tomography linear measurements Description Cone beam computed tomography volumetric measurements

Browse Conditions

Sequence: 193285562 Sequence: 193285563 Sequence: 193285564 Sequence: 193285565
Mesh Term Root Resorption Mesh Term Tooth Resorption Mesh Term Tooth Diseases Mesh Term Stomatognathic Diseases
Downcase Mesh Term root resorption Downcase Mesh Term tooth resorption Downcase Mesh Term tooth diseases Downcase Mesh Term stomatognathic diseases
Mesh Type mesh-list Mesh Type mesh-ancestor Mesh Type mesh-ancestor Mesh Type mesh-ancestor

Sponsors

Sequence: 48272374
Agency Class OTHER
Lead Or Collaborator lead
Name Al-Azhar University

Overall Officials

Sequence: 29256131
Role Principal Investigator
Name Mahmoud S Nassar, student
Affiliation Al-Azhar University

Design Group Interventions

Sequence: 68080840 Sequence: 68080841 Sequence: 68080842
Design Group Id 55537581 Design Group Id 55537582 Design Group Id 55537583
Intervention Id 52434413 Intervention Id 52434414 Intervention Id 52434415

Eligibilities

Sequence: 30736238
Gender All
Minimum Age 12 Years
Maximum Age 16 Years
Healthy Volunteers Accepts Healthy Volunteers
Criteria Inclusion Criteria: Patient will be included in this study if has: An age range between 12 and 16 years. Deep overbite with excessive curve of Spee of more than 5mm Over erupted lower incisors. Permanent teeth are all present (except for third molar). No previous orthodontic treatment. No indications or symptoms of periodontal disease in the past or present, as determined by clinical and radiographic examination Exclusion Criteria: Patients who needed surgery to fix skeletal problems. Any previous trauma or root canal therapy Missing lower incisor. Patients with congenital dentoskeletal disorders
Adult False
Child True
Older Adult False

Calculated Values

Sequence: 254018469
Number Of Facilities 1
Registered In Calendar Year 2022
Were Results Reported False
Has Us Facility False
Has Single Facility True
Minimum Age Num 12
Maximum Age Num 16
Minimum Age Unit Years
Maximum Age Unit Years
Number Of Primary Outcomes To Measure 2

Designs

Sequence: 30482597
Allocation Randomized
Intervention Model Parallel Assignment
Observational Model
Primary Purpose Basic Science
Time Perspective
Masking None (Open Label)
Masking Description Observation: Each patient will be followed up on periodic base for progress evaluation and integrity checks, as well as root resorption will be evaluated using CBCT images taken before and after the intrusion. Ethical considerations: An informed consent form (attached copy) that explains every step in the research will be given and discussed carefully with the patient and his/her parents before participation in the study and should be signed freely. The objectives of the study will be discussed and explained with the patients and / or their guardians and they will receive a copy of the consent form as well. Data management and analysis: The data will be collected, tabulated, and statistically analyzed using Statistical Package for Social Sciences (SPSS program, version 18, Inc., Chicago, III).
Intervention Model Description The total sample of patients will be randomly divided into three equal groups: Miniscrew: 7 patients will receive an intrusive force delivered by elastics from 2 miniscrews between mandibular lateral incisor and mandibular canine. Utility arch: 7 patients will receive an intrusive force delivered by intrusive utility arch. Nitinol reverse curve wire: 7 patients will receive an intrusive force delivered by Nitinol reverse curve wire.

Responsible Parties

Sequence: 28848949
Responsible Party Type Principal Investigator
Name Mahmoud Salah Mahmoud Ali Nassar
Title Principle investigator
Affiliation Al-Azhar University

Study References

Sequence: 52013815 Sequence: 52013816 Sequence: 52013817 Sequence: 52013818 Sequence: 52013819 Sequence: 52013820 Sequence: 52013821 Sequence: 52013822 Sequence: 52013823
Pmid 25737942 Pmid 31306077 Pmid 35330027 Pmid 1763835 Pmid 18684706 Pmid 32284893 Pmid 29390172 Pmid 6937401 Pmid 267433
Reference Type background Reference Type background Reference Type background Reference Type background Reference Type background Reference Type background Reference Type background Reference Type background Reference Type background
Citation Goel P, Tandon R, Agrawal KK. A comparative study of different intrusion methods and their effect on maxillary incisors. J Oral Biol Craniofac Res. 2014 Sep-Dec;4(3):186-91. doi: 10.1016/j.jobcr.2014.11.007. Epub 2014 Dec 6. Citation Hamdan AM, Lewis SM, Kelleher KE, Elhady SN, Lindauer SJ. Does overbite reduction affect smile esthetics? Angle Orthod. 2019 Nov;89(6):847-854. doi: 10.2319/030819-177.1. Epub 2019 Jul 15. Citation Piancino MG, Tortarolo A, Di Benedetto L, Crincoli V, Falla D. Chewing Patterns and Muscular Activation in Deep Bite Malocclusion. J Clin Med. 2022 Mar 19;11(6):1702. doi: 10.3390/jcm11061702. Citation Nielsen IL. Vertical malocclusions: etiology, development, diagnosis and some aspects of treatment. Angle Orthod. 1991 Winter;61(4):247-60. doi: 10.1043/0003-3219(1991)0612.0.CO;2. Erratum In: Angle Orthod 1992 Summer;62(2):87. Citation Sonnesen L, Svensson P. Temporomandibular disorders and psychological status in adult patients with a deep bite. Eur J Orthod. 2008 Dec;30(6):621-9. doi: 10.1093/ejo/cjn044. Epub 2008 Aug 5. Citation Guven BA, Ciger S. Evaluation of the Effect of Fixed Anterior Biteplane Treatment on Temporomandibular Joint in Patients with Deep Bite. Turk J Orthod. 2020 Mar 1;33(1):8-12. doi: 10.5152/TurkJOrthod.2020.19108. eCollection 2020 Mar. Citation Millett DT, Cunningham SJ, O'Brien KD, Benson PE, de Oliveira CM. Orthodontic treatment for deep bite and retroclined upper front teeth in children. Cochrane Database Syst Rev. 2018 Feb 1;2(2):CD005972. doi: 10.1002/14651858.CD005972.pub4. Citation Nanda R. The differential diagnosis and treatment of excessive overbite. Dent Clin North Am. 1981 Jan;25(1):69-84. No abstract available. Citation Burstone CR. Deep overbite correction by intrusion. Am J Orthod. 1977 Jul;72(1):1-22. doi: 10.1016/0002-9416(77)90121-x.