Lenkowski, J. R. & Raymond, P. A. Müller glia: Stem cells for generation and regeneration of retinal neurons in teleost fish. Prog. Retin Eye Res. 40, 94–123. https://doi.org/10.1016/j.preteyeres.2013.12.007 (2014).
Bringmann, A. et al. Müller cells in the healthy and diseased retina. Prog. Retin Eye Res. 25, 397–424. https://doi.org/10.1016/j.preteyeres.2006.05.003 (2006).
Karl, M. O. et al. Stimulation of neural regeneration in the mouse retina. Proc. Natl. Acad. Sci. USA 105, 19508–19513. https://doi.org/10.1073/pnas.0807453105 (2008).
Löffler, K., Schäfer, P., Völkner, M., Holdt, T. & Karl, M. O. Age-dependent Müller glia neurogenic competence in the mouse retina. Glia 63, 1809–1824. https://doi.org/10.1002/glia.22846 (2015).
Hamon, A. et al. Linking YAP to Müller glia quiescence exit in the degenerative retina. Cell Rep. 27, 1712-1725 e1716. https://doi.org/10.1016/j.celrep.2019.04.045 (2019).
Rueda, E. M. et al. The Hippo pathway blocks mammalian retinal Müller glial cell reprogramming. Cell Rep 27(1637–1649), e1636. https://doi.org/10.1016/j.celrep.2019.04.047 (2019).
Pollak, J. et al. ASCL1 reprograms mouse Müller glia into neurogenic retinal progenitors. Development 140, 2619–2631. https://doi.org/10.1242/dev.091355 (2013).
Ueki, Y. et al. Transgenic expression of the proneural transcription factor Ascl1 in Müller glia stimulates retinal regeneration in young mice. Proc. Natl. Acad. Sci. USA 112, 13717–13722. https://doi.org/10.1073/pnas.1510595112 (2015).
Jorstad, N. L. et al. Stimulation of functional neuronal regeneration from Müller glia in adult mice. Nature 548, 103–107. https://doi.org/10.1038/nature23283 (2017).
Hoang, T. et al. Gene regulatory networks controlling vertebrate retinal regeneration. Science https://doi.org/10.1126/science.abb8598 (2020).
Palazzo, I. et al. NFkB-signaling promotes glial reactivity and suppresses Müller glia-mediated neuron regeneration in the mammalian retina. Glia 70, 1380–1401. https://doi.org/10.1002/glia.24181 (2022).
Thummel, R., Kassen, S. C., Montgomery, J. E., Enright, J. M. & Hyde, D. R. Inhibition of Müller glial cell division blocks regeneration of the light-damaged zebrafish retina. Dev. Neurobiol. 68, 392–408. https://doi.org/10.1002/dneu.20596 (2008).
Thomas, J. L., Ranski, A. H., Morgan, G. W. & Thummel, R. Reactive gliosis in the adult zebrafish retina. Exp. Eye Res. 143, 98–109. https://doi.org/10.1016/j.exer.2015.09.017 (2016).
Joly, S., Pernet, V., Samardzija, M. & Grimm, C. Pax6-positive Müller glia cells express cell cycle markers but do not proliferate after photoreceptor injury in the mouse retina. Glia 59, 1033–1046. https://doi.org/10.1002/glia.21174 (2011).
Suga, A., Sadamoto, K., Fujii, M., Mandai, M. & Takahashi, M. Proliferation potential of Müller glia after retinal damage varies between mouse strains. PloS One 9, e94556. https://doi.org/10.1371/journal.pone.0094556 (2014).
Nomura-Komoike, K., Saitoh, F., Komoike, Y. & Fujieda, H. DNA damage response in proliferating Müller glia in the mammalian retina. Invest. Ophthalmol. Vis. Sci. 57, 1169–1182. https://doi.org/10.1167/iovs.15-18101 (2016).
Kato, M., Sudou, N., Nomura-Komoike, K., Iida, T. & Fujieda, H. Age- and cell cycle-related expression patterns of transcription factors and cell cycle regulators in Müller glia. Sci. Rep. 12, 19584. https://doi.org/10.1038/s41598-022-23855-w (2022).
Nomura-Komoike, K., Saitoh, F. & Fujieda, H. Phosphatidylserine recognition and Rac1 activation are required for Müller glia proliferation, gliosis and phagocytosis after retinal injury. Sci. Rep. 10, 1488. https://doi.org/10.1038/s41598-020-58424-6 (2020).
Malumbres, M. & Barbacid, M. Mammalian cyclin-dependent kinases. Trends Biochem. Sci. 30, 630–641. https://doi.org/10.1016/j.tibs.2005.09.005 (2005).
Hagting, A., Karlsson, C., Clute, P., Jackman, M. & Pines, J. MPF localization is controlled by nuclear export. EMBO J. 17, 4127–4138. https://doi.org/10.1093/emboj/17.14.4127 (1998).
Bertrand, N., Castro, D. S. & Guillemot, F. Proneural genes and the specification of neural cell types. Nat. Rev. Neurosci. 3, 517–530. https://doi.org/10.1038/nrn874 (2002).
Tomita, K., Nakanishi, S., Guillemot, F. & Kageyama, R. Mash1 promotes neuronal differentiation in the retina. Genes Cells 1, 765–774. https://doi.org/10.1111/j.1365-2443.1996.tb00016.x (1996).
Akagi, T. et al. Requirement of multiple basic helix-loop-helix genes for retinal neuronal subtype specification. J. Biol. Chem. 279, 28492–28498. https://doi.org/10.1074/jbc.M400871200 (2004).
Matter-Sadzinski, L., Puzianowska-Kuznicka, M., Hernandez, J., Ballivet, M. & Matter, J. M. A bHLH transcriptional network regulating the specification of retinal ganglion cells. Development 132, 3907–3921. https://doi.org/10.1242/dev.01960 (2005).
Brzezinski, J. A., Kim, E. J., Johnson, J. E. & Reh, T. A. Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina. Development 138, 3519–3531. https://doi.org/10.1242/dev.064006 (2011).
Fausett, B. V., Gumerson, J. D. & Goldman, D. The proneural basic helix-loop-helix gene ascl1a is required for retina regeneration. J. Neurosci. 28, 1109–1117. https://doi.org/10.1523/JNEUROSCI.4853-07.2008 (2008).
Ramachandran, R., Fausett, B. V. & Goldman, D. Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway. Nat. Cell Biol. 12, 1101–1107. https://doi.org/10.1038/ncb2115 (2010).
Schäfer, P. & Karl, M. O. Prospective purification and characterization of Müller glia in the mouse retina regeneration assay. Glia 65, 828–847. https://doi.org/10.1002/glia.23130 (2017).
Nelson, B. R. et al. Genome-wide analysis of Müller glial differentiation reveals a requirement for Notch signaling in postmitotic cells to maintain the glial fate. PloS One 6, e22817. https://doi.org/10.1371/journal.pone.0022817 (2011).
Castro, D. S. et al. A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets. Genes Dev. 25, 930–945. https://doi.org/10.1101/gad.627811 (2011).
Yi, S. H. et al. Mash1 and neurogenin 2 enhance survival and differentiation of neural precursor cells after transplantation to rat brains via distinct modes of action. Mol. Ther. 16, 1873–1882. https://doi.org/10.1038/mt.2008.189 (2008).
Lacomme, M., Liaubet, L., Pituello, F. & Bel-Vialar, S. NEUROG2 drives cell cycle exit of neuronal precursors by specifically repressing a subset of cyclins acting at the G1 and S phases of the cell cycle. Mol. Cell Biol. 32, 2596–2607. https://doi.org/10.1128/MCB.06745-11 (2012).
Fisher, D. & Mechali, M. Vertebrate HoxB gene expression requires DNA replication. EMBO J. 22, 3737–3748. https://doi.org/10.1093/emboj/cdg352 (2003).
Pop, R. et al. A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression. PLoS Biol. https://doi.org/10.1371/journal.pbio.1000484 (2010).
Tusi, B. K. et al. Population snapshots predict early haematopoietic and erythroid hierarchies. Nature 555, 54–60. https://doi.org/10.1038/nature25741 (2018).
Tsubouchi, T. & Fisher, A. G. Reprogramming and the pluripotent stem cell cycle. Curr. Top. Dev. Biol. 104, 223–241. https://doi.org/10.1016/B978-0-12-416027-9.00007-3 (2013).
Wang, B., Pfeiffer, M. J., Schwarzer, C., Arauzo-Bravo, M. J. & Boiani, M. DNA replication is an integral part of the mouse oocyte’s reprogramming machinery. PloS One 9, e97199. https://doi.org/10.1371/journal.pone.0097199 (2014).
Nashun, B., Hill, P. W. & Hajkova, P. Reprogramming of cell fate: Epigenetic memory and the erasure of memories past. EMBO J. 34, 1296–1308. https://doi.org/10.15252/embj.201490649 (2015).
Todd, L. et al. Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of proneural bHLH transcription factors. Cell Rep. 37, 109857. https://doi.org/10.1016/j.celrep.2021.109857 (2021).
Gallina, D., Todd, L. & Fischer, A. J. A comparative analysis of Müller glia-mediated regeneration in the vertebrate retina. Exp. Eye Res. 123, 121–130. https://doi.org/10.1016/j.exer.2013.06.019 (2014).
Lahne, M., Li, J., Marton, R. M. & Hyde, D. R. Actin-cytoskeleton- and Rock-mediated INM are required for photoreceptor regeneration in the adult zebrafish retina. J. Neurosci. 35, 15612–15634. https://doi.org/10.1523/JNEUROSCI.5005-14.2015 (2015).
Ul Quraish, R., Sudou, N., Nomura-Komoike, K., Sato, F. & Fujieda, H. p27(KIP1) loss promotes proliferation and phagocytosis but prevents epithelial-mesenchymal transition in RPE cells after photoreceptor damage. Mol. Vis. 22, 1103–1121 (2016).
Simon, M. V., Prado Spalm, F. H., Politi, L. E. & Rotstein, N. P. Sphingosine-1-Phosphate is a crucial signal for migration of retina Müller glial clls. Invest. Ophthalmol. Vis. Sci. 56, 5808–5815. https://doi.org/10.1167/iovs.14-16195 (2015).
Schneider, L. et al. DNA damage in mammalian neural stem cells leads to astrocytic differentiation mediated by BMP2 signaling through JAK-STAT. Stem Cell Rep. 1, 123–138. https://doi.org/10.1016/j.stemcr.2013.06.004 (2013).
Schneider, L. Survival of neural stem cells undergoing DNA damage-induced astrocytic differentiation in self-renewal-promoting conditions in vitro. PloS One 9, e87228. https://doi.org/10.1371/journal.pone.0087228 (2014).
Guimaraes, R. P. M. et al. Evidence of Müller glia conversion into retina ganglion cells using Neurogenin2. Front. Cell Neurosci. 12, 410. https://doi.org/10.3389/fncel.2018.00410 (2018).
Cebolla, B. & Vallejo, M. Nuclear factor-I regulates glial fibrillary acidic protein gene expression in astrocytes differentiated from cortical precursor cells. J. Neurochem. 97, 1057–1070. https://doi.org/10.1111/j.1471-4159.2006.03804.x (2006).
Deneen, B. et al. The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron 52, 953–968. https://doi.org/10.1016/j.neuron.2006.11.019 (2006).
Dyer, M. A. & Cepko, C. L. Control of Müller glial cell proliferation and activation following retinal injury. Nat. Neurosci. 3, 873–880 (2000).
- SEO Powered Content & PR Distribution. Get Amplified Today.
- PlatoData.Network Vertical Generative Ai. Empower Yourself. Access Here.
- PlatoAiStream. Web3 Intelligence. Knowledge Amplified. Access Here.
- PlatoESG. Carbon, CleanTech, Energy, Environment, Solar, Waste Management. Access Here.
- PlatoHealth. Biotech and Clinical Trials Intelligence. Access Here.
- Source: https://www.nature.com/articles/s41598-023-50222-0