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Bio-Rad Laboratories gets grant for high-throughput genetic material isolation and processing system

According to GlobalData’s company profile on Bio-Rad Laboratories, Laboratory automation robots was a key innovation area identified from patents. Bio-Rad Laboratories‘s grant share as of February 2024 was 59%. Grant share is based on the ratio of number of grants to total number of patents.

High-throughput genetic material isolation and processing system

Source: United States Patent and Trademark Office (USPTO). Credit: Bio-Rad Laboratories Inc

A recently granted patent (Publication Number: US11865542B2) discloses a method for capturing and processing nucleic acid material. The method involves isolating genetic material from a sample within an array of wells defined within a substrate. Each well in the array extends into a planar surface of the substrate, with a fluid pathway passing across the array of wells. The genetic material is isolated with a population of probe-coupled particles at the array of wells, achieving a capture efficiency of over 80%. Process reagents are delivered into the fluid pathway, a layer of oil is distributed to prevent transfer between wells, heat is transmitted to process the genetic material, and the contents of each well are optically interrogated.

Furthermore, the method includes capturing the probe-coupled particles in single-particle format at a large number of wells, delivering process reagents using a pump, and distributing the layer of oil through pressure generation. Heat transmission involves probe hybridization and thermocycling, with a reflective heating surface reflecting light back into the wells. The substrate also features a fluid reservoir sealed by a lid with grooves for displacing fluid phases. The method allows for real-time fluorescence imaging, redistribution of contents exceeding well capacity, quantitative analysis of genetic material, and generation of a genotyping library. The fluid pathway includes inlet and outlet channels, and the genetic material can be derived from single cell lysate, with a lysis buffer delivered as part of the process reagents.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.