Arnold, S. J. & Robertson, E. J. Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo. Nat. Rev. Mol. Cell Biol. 10, 91–103 (2009).
Xu, P. F. et al. Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre. Nat. Commun. 12, 1–22 (2021).
van den Brink, S. C. et al. Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids. Nature 582, 405–409 (2020).
Rossi, G. et al. Capturing cardiogenesis in gastruloids. Cell Stem Cell 28, 230–240.e6 (2020).
Beccari, L. et al. Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids. Nature 562, 272–276 (2018).
Veenvliet, J. V. et al. Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites. Science 370, eaba4937 (2020).
Amadei, G. et al. Embryo model completes gastrulation to neurulation and organogenesis. Nature 610, 143–153 (2022).
Lau, K. Y. C. et al. Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development. Cell Stem Cell 29, 1445–1458.e8 (2022).
Harrison, S. E., Sozen, B., Christodoulou, N., Kyprianou, C. & Zernicka-Goetz, M. Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro. Science 356, eaal1810 (2017).
Harrison, S. E., Sozen, B. & Zernicka-Goetz, M. In vitro generation of mouse polarized embryo-like structures from embryonic and trophoblast stem cells. Nat. Protoc. 13, 1586–1602 (2018).
Sozen, B. et al. Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures. Nat. Cell Biol. 20, 979–989 (2018).
Shimosato, D., Shiki, M. & Niwa, H. Extra-embryonic endoderm cells derived from ES cells induced by GATA Factors acquire the character of XEN cells. BMC Dev. Biol. 7, 80 (2007).
Amadei, G. et al. Inducible stem-cell-derived embryos capture mouse morphogenetic events in vitro. Dev. Cell 56, 366–382.e9 (2021).
Sturm, K. & Tam, P. P. L. Isolation and culture of whole postimplantation embryos and germ layer derivatives. Methods Enzymol. 225, 164–190 (1993).
Aguilera-Castrejon, A. et al. Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis. Nature 593, 119–124 (2021).
Chawengsaksophak, K., James, R., Hammond, V. E., Köntgen, F. & Beck, F. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature 386, 84–87 (1997).
Strumpf, D. et al. Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development 132, 2093–2102 (2005).
Jedrusik, A. et al. Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo. Genes Dev. 22, 2692–2706 (2008).
Niwa, H. et al. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 123, 917–929 (2005).
Tanaka, S., Kunath, T., Hadjantonakis, A. K., Nagy, A. & Rossant, J. Promotion to trophoblast stem cell proliferation by FGF4. Science 282, 2072–2075 (1998).
Quinn, J., Kunath, T. & Rossant, J. Mouse trophoblast stem cells. Methods Mol. Med. 121, 125–148 (2006).
Seong, J. et al. Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero. Cell Stem Cell 29, 1102–1118.e8 (2022).
Tarazi, S. et al. Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs. Cell 185, 3290–3306.e25 (2022).
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