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Adult neurogenesis and aging mechanisms: a collection of insights – Scientific Reports

  • Quaresima, S. et al. Assessing the role of ependymal and vascular cells as sources of extracellular cues regulating the mouse ventricular-subventricular zone neurogenic niche. Front. Cell Dev. Biol. 10, 845567 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  • Denoth-Lippuner, A. & Jessberger, S. Formation and integration of new neurons in the adult hippocampus. Nat. Rev. Neurosci. 22, 223–236 (2021).

    Article  CAS  PubMed  Google Scholar 

  • Navarro Negredo, P., Yeo, R. W. & Brunet, A. Aging and rejuvenation of neural stem cells and their niches. Cell Stem. Cell 27, 202–223 (2020).

    Article  CAS  PubMed  Google Scholar 

  • Lupo, G., Gioia, R., Nisi, P. S., Biagioni, S. & Cacci, E. Molecular mechanisms of neurogenic aging in the adult mouse subventricular zone. J. Exp. Neurosci. 13, 1179069519829040 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  • Poulose, S. M., Miller, M. G., Scott, T. & Shukitt-Hale, B. Nutritional factors affecting adult neurogenesis and cognitive function. Adv. Nutr. Bethesda Md 8, 804–811 (2017).

    Article  CAS  Google Scholar 

  • Llorens-Martín, M. Exercising new neurons to vanquish Alzheimer disease. Brain Plast. Amst. Neth. 4, 111–126 (2018).

    Article  Google Scholar 

  • Sorrells, S. F. et al. Positive controls in adults and children support that very few, if any, new neurons are born in the adult human hippocampus. J. Neurosci. Off. J. Soc. Neurosci. 41, 2554–2565 (2021).

    Article  CAS  Google Scholar 

  • Moreno-Jiménez, E. P., Terreros-Roncal, J., Flor-García, M., Rábano, A. & Llorens-Martín, M. Evidences for adult hippocampal neurogenesis in humans. J. Neurosci. Off. J. Soc. Neurosci. 41, 2541–2553 (2021).

    Article  Google Scholar 

  • Sippel, D. et al. Disruption of NREM sleep and sleep-related spatial memory consolidation in mice lacking adult hippocampal neurogenesis. Sci. Rep. 10, 16467 (2020).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  • Hourigan, B., Balay, S. D., Yee, G., Sharma, S. & Tan, Q. Capicua regulates the development of adult-born neurons in the hippocampus. Sci. Rep. 11, 11725 (2021).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  • Schuele, L.-L. et al. Regulation of adult neurogenesis by the endocannabinoid-producing enzyme diacylglycerol lipase alpha (DAGLa). Sci. Rep. 12, 633 (2022).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  • Piyanova, A. et al. Age-related changes in the endocannabinoid system in the mouse hippocampus. Mech. Ageing Dev. 150, 55–64 (2015).

    Article  CAS  PubMed  Google Scholar 

  • Khuu, M. A. et al. Stage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis. Sci. Rep. 11, 6005 (2021).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  • Bonds, J. A. et al. Deficits in hippocampal neurogenesis in obesity-dependent and -independent type-2 diabetes mellitus mouse models. Sci. Rep. 10, 16368 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Arredondo, S. B. et al. Andrographolide promotes hippocampal neurogenesis and spatial memory in the APPswe/PS1ΔE9 mouse model of Alzheimer’s disease. Sci. Rep. 11, 22904 (2021).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  • Hwang, D. et al. Exogenous lactate augments exercise-induced improvement in memory but not in hippocampal neurogenesis. Sci. Rep. 13, 5838 (2023).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  • Sanai, N. et al. Corridors of migrating neurons in the human brain and their decline during infancy. Nature 478, 382–386 (2011).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  • Tepper, B. et al. Impaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums. Sci. Rep. 11, 4418 (2021).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  • Bitar, M. et al. Identifying gene expression profiles associated with neurogenesis and inflammation in the human subependymal zone from development through aging. Sci. Rep. 12, 40 (2022).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  • Kalamakis, G. et al. Quiescence modulates stem cell maintenance and regenerative capacity in the aging brain. Cell 176, 1407-1419.e14 (2019).

    Article  CAS  PubMed  Google Scholar 

  • Sharif, A., Fitzsimons, C. P. & Lucassen, P. J. Neurogenesis in the adult hypothalamus: A distinct form of structural plasticity involved in metabolic and circadian regulation, with potential relevance for human pathophysiology. Handb. Clin. Neurol. 179, 125–140 (2021).

    Article  PubMed  Google Scholar 

  • Engel, D. F. et al. Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms. Sci. Rep. 10, 11047 (2020).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  • Brown, S. J. et al. PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons. Sci. Rep. 11, 6617 (2021).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  • Sánchez-González, R., Salvador, N. & López-Mascaraque, L. Unraveling the adult cell progeny of early postnatal progenitor cells. Sci. Rep. 10, 19058 (2020).

    Article  ADS  PubMed  PubMed Central  Google Scholar 

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