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A CAAR NK cell approach to eliminate pathogenic autoantibody-secreting cells – Nature Reviews Nephrology

Binding of autoantibodies to autoantigens expressed on podocytes causes membranous nephropathy. New findings suggest that chimeric autoantibody receptor (CAAR) natural killer (NK) cells could be used to eliminate pathogenic autoantibody-producing cells in this disease.

The researchers conclude that CAAR NK and T cells can eliminate antibody-secreting target cells in an antigen-specific manner, demonstrating the feasibility of this strategy as a therapeutic approach. They suggest that use of their CAAR NK cell strategy might enable an off-the-shelf treatment with high specificity, low adverse effects and reduced long-term complications, patient burden and treatment costs compared to use of a more conventional autologous chimeric antigen receptor T cell approach.